Department of Cellular - Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, PO Box: 14155-6447, Tehran, Iran.
Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
BMC Endocr Disord. 2022 Sep 19;22(1):234. doi: 10.1186/s12902-022-01129-w.
Recent studies have shown that obesity is largely influenced by heredity and created by the interactions between several genes and environmental and behavioral factors. This study aimed to examine association between variant rs17782313 near melanocortin-4 receptor (MC4R) gene and behavioral and hormonal factors then evaluated interactions between variant MC4R rs17782313 with behavioral and hormonal factors on obesity.
This cross-sectional study included 403 subjects, overweight and/or obesity, aged 20-50 years from Iran. The MC4R rs17782313 data were measured by the PCR-RFLP method. Dietary intake, physical activity, stress, anxiety, depression, appetite and emotional eating were assessed by using validated questionnaires. Ghrelin, glucagon-like peptide-1 and cortisol were measured by radioimmunoassay in plasma samples. Participants were also divided into three groups based on rs17782313 genotype and BMI.
After adjustment for age, gender, energy intake and PA, significant associations were observed between food intake, appetite, emotional eating, stress and physical activity with MC4R rs17782313 (p ˂0.05). Also, significant interactions were observed between fat intake (p-interaction = 0.002), protein intake (p-interaction = 0.01), energy intake (p-interaction = 0.01), emotional eating (p-interaction = 0.02), appetite (p-interaction = 0.04), stress (p-interaction = 0.04), ghrelin (p-interaction = 0.03), cortisol (p-interaction = 0.04) and physical activity (p-interaction = 0.04) and MC4R rs17782313 in terms of BMI.
Interactions between the CC genotype and high intakes of fat and energy, emotional eating, high appetite, and too much stress with high levels of cortisol and ghrelin probably can have an effect on BMI in overweight/obese subjects.
最近的研究表明，肥胖在很大程度上受遗传因素影响，并由几个基因与环境和行为因素之间的相互作用所导致。本研究旨在探讨黑素皮质素受体 4 基因（MC4R）附近的变异 rs17782313 与行为和激素因素之间的关联，然后评估变异 MC4R rs17782313 与行为和激素因素对肥胖的相互作用。
本横断面研究纳入了 403 名伊朗 20-50 岁超重和/或肥胖患者。MC4R rs17782313 数据通过 PCR-RFLP 法进行测量。通过使用经过验证的问卷评估饮食摄入、体力活动、压力、焦虑、抑郁、食欲和情绪性进食。使用放射免疫法测量血浆样本中的 ghrelin、胰高血糖素样肽-1 和皮质醇。根据 rs17782313 基因型和 BMI 将参与者分为三组。
在调整年龄、性别、能量摄入和体力活动后，MC4R rs17782313 与食物摄入、食欲、情绪性进食、压力和体力活动之间存在显著关联（p ˂0.05）。此外，还观察到脂肪摄入（p 交互=0.002）、蛋白质摄入（p 交互=0.01）、能量摄入（p 交互=0.01）、情绪性进食（p 交互=0.02）、食欲（p 交互=0.04）、压力（p 交互=0.04）、ghrelin（p 交互=0.03）、皮质醇（p 交互=0.04）和体力活动（p 交互=0.04）与 MC4R rs17782313 之间存在显著的交互作用，从而影响 BMI。
CC 基因型与高脂肪和高能量摄入、情绪性进食、高食欲和高皮质醇水平与高 ghrelin 水平之间的相互作用，以及压力过大，可能会对超重/肥胖患者的 BMI 产生影响。
