Fan Wangxi, Fu Xiuqin, Li Zefang, Ou Junfei, Yang Zhou, Xiang Meng, Qin Zhongli
School of Materials Engineering, Jiangsu University of Technology, Changzhou 213001, China.
School of Life Science and Technology, Wuhan Bioengineering Institute, Wuhan 430415, China.
Materials (Basel). 2021 Oct 14;14(20):6065. doi: 10.3390/ma14206065.
Ultrahigh molecular weight polyethylene (UHMWPE) materials have been prevalent joint replacement materials for more than 45 years because of their excellent biocompatibility and wear resistance. In this study, functionalized activated nanocarbon (FANC) was prepared by grafting maleic anhydride polyethylene onto acid-treated activated nanocarbon. A novel porous UHMWPE composite was prepared by incorporating the appropriate amount of FANC and pore-forming agents during the hot-pressing process for medical UHMWPE powder. The experimental results showed that the best prepared porous UHMWPE/FANC exhibited appropriate tensile strength, porosity, and excellent hydrophilicity, with a contact angle of 65.9°. In vitro experiments showed that the porous UHMWPE/FANC had excellent biocompatibility, which is due to its porous structure and hydrophilicity caused by FANC. This study demonstrates the potential viability for our porous UHMWPE/FANC to be used as cartilage replacement material for biomedical applications.
超高分子量聚乙烯（UHMWPE）材料因其优异的生物相容性和耐磨性，已成为45年多来普遍使用的关节置换材料。在本研究中，通过将马来酸酐聚乙烯接枝到酸处理的活性纳米碳上制备了功能化活性纳米碳（FANC）。通过在医用UHMWPE粉末的热压过程中加入适量的FANC和成孔剂，制备了一种新型多孔UHMWPE复合材料。实验结果表明，制备的最佳多孔UHMWPE/FANC具有合适的拉伸强度、孔隙率和优异的亲水性，接触角为65.9°。体外实验表明，多孔UHMWPE/FANC具有优异的生物相容性，这归因于其多孔结构和FANC引起的亲水性。本研究证明了我们的多孔UHMWPE/FANC作为生物医学应用的软骨替代材料的潜在可行性。
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