Huang Huanshao, Wang Jiajun, Zhang Junai, Cai Jiye, Pi Jiang, Xu Jun-Fa
Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan 523808, China.
Department of Chemistry, Jinan University, Guangzhou 510632, China.
Pharmaceutics. 2021 Oct 2;13(10):1599. doi: 10.3390/pharmaceutics13101599.
Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element. Current cancer treatment strategies, including chemotherapy and radiotherapy, have been seriously restricted by their side effects and low efficiency for a long time, which urges us to develop new technologies for more effective and much safer anticancer therapies. Novel nanotechnologies, based on different kinds of functional nanomaterials, have been proved to act as effective and promising strategies for anticancer treatment. Based on the important biological roles of cobalt, cobalt oxide nanoparticles (NPs) have been widely developed for their attractive biomedical applications, especially their potential for anticancer treatments due to their selective inhibition of cancer cells. Thus, more and more attention has been attracted to the preparation, characterization and anticancer investigation of cobalt oxide nanoparticles in recent years, which is expected to introduce novel anticancer treatment strategies. In this review, we summarize the synthesis methods of cobalt oxide nanoparticles to discuss the advantages and restrictions for their preparation. Moreover, we emphatically discuss the anticancer functions of cobalt oxide nanoparticles as well as their underlying mechanisms to promote the development of cobalt oxide nanoparticles for anticancer treatments, which might finally benefit the current anticancer therapeutics based on functional cobalt oxide nanoparticles.
钴对所有动物的新陈代谢至关重要，因为它在钴胺素（也称为维生素B12）的代谢中起着关键作用，而钴胺素是钴作为超微量元素的主要生物储存库。目前的癌症治疗策略，包括化疗和放疗，长期以来一直受到其副作用和低效率的严重限制，这促使我们开发新技术以实现更有效、更安全的抗癌治疗。基于不同功能纳米材料的新型纳米技术已被证明是有效的、有前景的抗癌治疗策略。基于钴的重要生物学作用，氧化钴纳米颗粒已因其有吸引力的生物医学应用而得到广泛开发，特别是因其对癌细胞具有选择性抑制作用而在抗癌治疗方面具有潜力。因此，近年来氧化钴纳米颗粒的制备、表征及抗癌研究越来越受到关注，有望引入新的抗癌治疗策略。在这篇综述中，我们总结了氧化钴纳米颗粒的合成方法，以讨论其制备的优点和限制。此外，我们着重讨论氧化钴纳米颗粒的抗癌功能及其潜在机制，以推动氧化钴纳米颗粒用于抗癌治疗的发展，这最终可能会使基于功能性氧化钴纳米颗粒的当前抗癌疗法受益。
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