Key Laboratory of Xin' an Medicine Ministry of Education, Anhui Province Key Laboratory of Chinese Medicinal Formula; Anhui Province Key Laboratory of Pharmaceutical Technology and Application; Anhui Province Key Laboratory of R & D of Chinese Medicine; Anhui University of Traditional Chinese Medicine, Hefei, Anhui, 230038, China.
Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, 230001, China.
Curr Drug Targets. 2021;22(8):913-921. doi: 10.2174/1389450122666210127100430.
Systemic chemotherapy and radiotherapy have been widely used in clinics for several decades, but their disadvantages, such as systemic cytotoxicity and severe side effects, are the biggest obstacle to maximum therapeutic efficacy. In recent years, the impact of extracellular matrix components in tumor progression has gained the attention of researchers, and with the rapid development of nanomaterials, extracellular matrix targeted nanomaterials have become a promising strategy in tumor theranostics. In this review, we will outline the recent and relevant examples of various tumor extracellular matrix targeted nanomaterials applied in tumor therapy and imaging. And we will discuss the challenges and prospects of nanomaterials for future tumor therapy.
几十年来，系统化疗和放疗在临床上得到了广泛应用，但它们的缺点，如全身细胞毒性和严重的副作用，是最大限度发挥治疗效果的最大障碍。近年来，细胞外基质成分在肿瘤进展中的影响引起了研究人员的关注，随着纳米材料的快速发展，细胞外基质靶向纳米材料已成为肿瘤治疗和诊断的一种有前途的策略。在这篇综述中，我们将概述各种应用于肿瘤治疗和成像的肿瘤细胞外基质靶向纳米材料的最新相关实例。我们还将讨论纳米材料在未来肿瘤治疗中的挑战和前景。
