Karska-Basta Izabella, Pociej-Marciak Weronika, Chrząszcz Michał, Kubicka-Trząska Agnieszka, Dębicka-Kumela Magdalena, Gawęcki Maciej, Romanowska-Dixon Bożena, Sanak Marek
Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
Dobry Wzrok Ophthalmological Clinic, 80-402 Gdansk, Poland.
J Clin Med. 2021 Mar 5;10(5):1087. doi: 10.3390/jcm10051087.
The pathogenesis of central serous chorioretinopathy (CSC) remains a subject of intensive research. We aimed to determine correlations between plasma levels of selected angiogenic factors and different forms of CSC.
Eighty patients were enrolled in the study including 30 with a chronic form of CSC, 30 with acute CSC, and 20 controls. Presence of active CSC was determined by fluorescein angiography (FA), indocyanine green angiography (ICGA), and swept-source optical coherence tomography (SS-OCT). Plasma concentrations of angiopoietin-1, endostatin, fibroblast growth factor, placental growth factor (PlGF), platelet-derived growth factor (PDGF-AA), thrombospondin-2, vascular endothelial growth factor (VEGF), VEGF-D, and pigment epithelium-derived factor were measured, and the results were compared between groups. Additionally, mean choroidal thickness (CT) was measured in all patients.
Levels of angiopoietin-1 ( = 0.008), PlGF ( = 0.045), and PDGF-AA ( = 0.033) differed significantly between the three groups. Compared with the controls, VEGF ( = 0.024), PlGF ( = 0.013), and PDGF-AA ( = 0.012) were downregulated in the whole CSC group, specifically PDGF-AA ( = 0.002) in acute CSC and angiopoietin-1 ( = 0.007) in chronic CSC. An inverse correlation between mean CT and VEGF levels was noted in CSC patients ( = -0.27, = 0.044).
Downregulated angiopoietin-1, VEGF, PDGF-AA, and PlGF levels may highlight the previously unknown role of the imbalanced levels of proangiogenic and antiangiogenic factors in the pathogenesis of CSC. Moreover, downregulated VEGF levels may suggest that choroidal neovascularization in CSC is associated with arteriogenesis rather than angiogenesis.
中心性浆液性脉络膜视网膜病变（CSC）的发病机制仍是深入研究的课题。我们旨在确定特定血管生成因子的血浆水平与不同形式的CSC之间的相关性。
80名患者纳入本研究，其中30例为慢性CSC患者，30例为急性CSC患者，20例为对照组。通过荧光素血管造影（FA）、吲哚菁绿血管造影（ICGA）和扫频光学相干断层扫描（SS-OCT）确定活动性CSC的存在。测量血管生成素-1、内皮抑素、成纤维细胞生长因子、胎盘生长因子（PlGF）、血小板衍生生长因子（PDGF-AA）、血小板反应蛋白-2、血管内皮生长因子（VEGF）、VEGF-D和色素上皮衍生因子的血浆浓度，并在组间比较结果。此外，测量所有患者的平均脉络膜厚度（CT）。
三组之间血管生成素-1（P = 0.008）、PlGF（P = 0.045）和PDGF-AA（P = 0.033）水平存在显著差异。与对照组相比，整个CSC组中VEGF（P = 0.024）、PlGF（P = 0.013）和PDGF-AA（P = 0.012）下调，急性CSC中PDGF-AA（P = 0.002）和慢性CSC中血管生成素-1（P = 0.007）尤为明显。CSC患者中观察到平均CT与VEGF水平呈负相关（P = -0.27，P = 0.044）。
血管生成素-1、VEGF、PDGF-AA和PlGF水平下调可能凸显了促血管生成和抗血管生成因子水平失衡在CSC发病机制中先前未知的作用。此外，VEGF水平下调可能表明CSC中的脉络膜新生血管形成与动脉生成而非血管生成有关。
