小鼠红白血病Friend细胞分化过程中c-myc表达的转录和转录后调控
Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells.
作者信息
Mechti N, Piechaczyk M, Blanchard J M, Marty L, Bonnieu A, Jeanteur P, Lebleu B
出版信息
Nucleic Acids Res. 1986 Dec 22;14(24):9653-66. doi: 10.1093/nar/14.24.9653.
Abstract
c-myc RNA rapidly decreases to barely detectable levels in Friend erythroleukemia cells induced to differentiate upon the addition of dimethylsulfoxide. We show here that c-myc gene is down-regulated both at the transcriptional level presumably by a block in the elongation of primary transcripts and at the post-transcriptional level by an increase in the degradation of its mRNA.
摘要
在添加二甲基亚砜后诱导分化的弗氏红白血病细胞中，c-myc RNA迅速减少至几乎检测不到的水平。我们在此表明，c-myc基因在转录水平上可能因初级转录本延伸受阻而下调，在转录后水平上则因mRNA降解增加而下调。
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