Coordinación para la Innovación de la Ciencia y la Tecnología (CIACYT), Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Sierra Leona #550, Col. Lomas de San Luis, San Luis Potosí C.P. 78210, Mexico.
Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas s/n, Col. Las Campanas, Santiago de Querétaro, Querétaro C.P. 76010, Mexico.
Molecules. 2021 Oct 19;26(20):6311. doi: 10.3390/molecules26206311.
are used as a broad-spectrum medical insect in the alternative treatment of various diseases. Preliminary volatilome studies carried out to date have shown, as the main components, methyl-1,4-benzoquinone, ethyl-1,4-benzoquinone, 1-tridecene, 1-pentadecene, and limonene. This work focused on the production of metabolites and their metabolic variations in under stress conditions to provide additional valuable information to help better understand the broad-spectrum medical uses. To this end, VOCs were characterized by HS-SPME with PEG and CAR/PDMS fibers, and the first reported insect essential oils were obtained. In HS-SMPE, we found 17 terpenes, six quinones, five alkenes, and four aromatic compounds; in the essential oils, 53 terpenes, 54 carboxylic acids and derivatives, three alkynes, 12 alkenes (1-Pentadecene, EOT1: 77.6% and EOT2: 57.9%), 28 alkanes, nine alkyl disulfides, three aromatic compounds, 19 alcohols, three quinones, and 12 aldehydes were identified. Between both study approaches, a total of 171 secondary metabolites were identified with no previous report for . A considerable number of the identified metabolites showed previous studies of the activity of pharmacological interest. Therefore, considering the wide variety of activities reported for these metabolites, this work allows a broader vision of the therapeutic potential of in traditional medicine.
被用作替代治疗各种疾病的广谱药用昆虫。迄今为止进行的初步挥发物研究表明，其主要成分包括甲基-1,4-苯醌、乙基-1,4-苯醌、1-十三烯、1-十五烯和柠檬烯。这项工作侧重于在胁迫条件下产生代谢物及其代谢变化，以提供额外有价值的信息，帮助更好地理解其广谱药用用途。为此，我们采用 HS-SPME 结合 PEG 和 CAR/PDMS 纤维对 VOCs 进行了表征，并获得了首次报道的昆虫精油。在 HS-SMPE 中，我们发现了 17 种萜类化合物、6 种醌类化合物、5 种烯烃和 4 种芳香族化合物；在精油中，发现了 53 种萜类化合物、54 种羧酸及其衍生物、3 种炔烃、12 种烯烃（1-十五烯，EOT1：77.6%和 EOT2：57.9%）、28 种烷烃、9 种烷基二硫化物、3 种芳香族化合物、19 种醇类、3 种醌类和 12 种醛类。在这两种研究方法中，共鉴定出 171 种次生代谢物，这些代谢物在 中尚无先前报道。鉴定出的许多代谢物都具有先前研究的药理活性。因此，考虑到这些代谢物报道的广泛的活性，这项工作使我们对 在传统医学中的治疗潜力有了更广泛的认识。
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