Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, WA 6150, Australia.
School of Medicine, University of Western Australia, Perth, WA 6009, Australia.
Cells. 2021 Sep 28;10(10):2573. doi: 10.3390/cells10102573.
Acute coronary syndrome (ACS) describes a range of conditions associated with the rupture of high-risk or vulnerable plaque. Vulnerable atherosclerotic plaque is associated with many changes in its microenvironment which could potentially cause rapid plaque progression. Present-day PET imaging presents a plethora of radiopharmaceuticals designed to image different characteristics throughout plaque progression. Improved knowledge of atherosclerotic disease pathways has facilitated a growing number of pathophysiological targets for more innovative radiotracer design aimed at identifying at-risk vulnerable plaque and earlier intervention opportunity. This paper reviews the efficacy of PET imaging radiotracers F-FDG, F-NaF, Ga-DOTATATE, Cu-DOTATATE and Ga-pentixafor in plaque characterisation and risk assessment, as well as the translational potential of novel radiotracers in animal studies. Finally, we discuss our murine PET imaging experience and the challenges encountered.
急性冠状动脉综合征（ACS）描述了一系列与高危或易损斑块破裂相关的病症。易损动脉粥样硬化斑块与其微环境中的许多变化有关，这些变化可能导致斑块迅速进展。目前的正电子发射断层扫描（PET）成像技术提供了大量放射性药物，旨在对斑块进展过程中的不同特征进行成像。对动脉粥样硬化疾病途径的认识不断提高，为更具创新性的放射性示踪剂设计提供了越来越多的病理生理靶点，旨在识别高危易损斑块和更早的干预机会。本文综述了正电子发射断层扫描（PET）成像放射性示踪剂 F-FDG、F-NaF、Ga-DOTATATE、Cu-DOTATATE 和 Ga-pentixafor 在斑块特征描述和风险评估中的疗效，以及新型放射性示踪剂在动物研究中的转化潜力。最后，我们讨论了我们的小鼠 PET 成像经验和遇到的挑战。
Zotero 插件
