Grupo de Química Neuro-Regenerativa, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain.
Servicio de Radiología, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain.
Cells. 2021 Oct 17;10(10):2783. doi: 10.3390/cells10102783.
Aldynoglia are growth-promoting cells with a morphology similar to radial glia and share properties and markers with astrocytes and Schwann cells. They are distributed in several locations throughout the adult central nervous system, where the cells of the aldynoglia interact and respond to the signals of the immune cells. After spinal cord injury (SCI), the functions of resident aldynoglia, identified as ependymocytes, tanycytes, and ependymal stem cells (EpSCs) of the spinal cord are crucial for the regeneration of spinal neural tissue. These glial cells facilitate axonal regrowth and remyelination of injured axons. Here, we review the influence of M1 or M2 macrophage/microglia subpopulations on the fate of EpSCs during neuroinflammation and immune responses in the acute, subacute, and chronic phases after SCI.
阿尔丁诺利亚是具有类似于放射状胶质细胞形态的促生长细胞，与星形胶质细胞和许旺细胞具有共同的特性和标志物。它们分布在成年中枢神经系统的多个部位，在这些部位，阿尔丁诺利亚细胞与免疫细胞的信号相互作用并作出响应。在脊髓损伤（SCI）后，驻留的阿尔丁诺利亚细胞的功能，如脊髓室管膜细胞、室管膜下区细胞和室管膜下干细胞（EpSCs），对于脊髓神经组织的再生至关重要。这些神经胶质细胞促进损伤轴突的轴突再生和髓鞘形成。在这里，我们综述了 M1 或 M2 巨噬细胞/小胶质细胞亚群在 SCI 后急性、亚急性和慢性阶段的神经炎症和免疫反应过程中对 EpSCs 命运的影响。
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