Kim Su Jin, Cho Young Sam, Park Jong Mok, Na Young Gil, Kim Khae Hawn
Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Int Neurourol J. 2020 May;24(Suppl 1):S3-10. doi: 10.5213/inj.2040150.075. Epub 2020 May 31.
Neurogenic bladder (NB) after spinal cord injury (SCI) is a common complication that inhibits normal daily activities and reduces the quality of life. Regrettably, the current therapeutic methods for NB are inadequate. Therefore, numerous studies have been conducted to develop new treatments for NB associated with SCI. Moreover, a myriad of preclinical and clinical trials on the effects and safety of stem cell therapy in patients with SCI have been performed, and several studies have demonstrated improvements in urodynamic parameters, as well as in sensory and motor function, after stem cell therapy. These results are promising; however, further high-quality clinical studies are necessary to compensate for a lack of randomized trials, the modest number of participants, variation in the types of stem cells used, and inconsistency in routes of administration.
脊髓损伤（SCI）后的神经源性膀胱（NB）是一种常见并发症，会妨碍正常日常活动并降低生活质量。遗憾的是，目前针对NB的治疗方法并不充分。因此，人们开展了大量研究来开发针对与SCI相关的NB的新疗法。此外，已经针对SCI患者进行了无数关于干细胞疗法效果和安全性的临床前和临床试验，并且多项研究表明，干细胞治疗后尿动力学参数以及感觉和运动功能都有所改善。这些结果很有前景；然而，由于缺乏随机试验、参与者数量有限、所用干细胞类型的差异以及给药途径的不一致，仍需要进一步开展高质量的临床研究。
