The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Cell Rep. 2021 Oct 19;37(3):109837. doi: 10.1016/j.celrep.2021.109837.
The selection of goal-directed behaviors is supported by neural circuits located within the frontal cortex. Frontal cortical afferents arise from multiple brain areas, yet the cell-type-specific targeting of these inputs is unclear. Here, we use monosynaptic retrograde rabies mapping to examine the distribution of afferent neurons targeting distinct classes of local inhibitory interneurons and excitatory projection neurons in mouse infralimbic frontal cortex. Interneurons expressing parvalbumin, somatostatin, or vasoactive intestinal peptide receive a large proportion of inputs from the hippocampus, while interneurons expressing neuron-derived neurotrophic factor receive a large proportion of inputs from thalamic regions. A similar dichotomy is present among the four different excitatory projection neurons. These results show a prominent bias among long-range hippocampal and thalamic afferent systems in their targeting to specific sets of frontal cortical neurons. Moreover, they suggest the presence of two distinct local microcircuits that control how different inputs govern frontal cortical information processing.
目标导向行为的选择由位于额叶皮层内的神经回路支持。额叶皮质传入来自多个脑区，但这些输入的细胞类型特异性靶向尚不清楚。在这里，我们使用单突触逆行狂犬病毒映射来检查靶向小鼠下边缘额皮质中不同类别的局部抑制性中间神经元和兴奋性投射神经元的传入神经元的分布。表达钙蛋白、生长抑素或血管活性肠肽的中间神经元接收来自海马体的大量输入，而表达神经元衍生神经营养因子的中间神经元接收来自丘脑区域的大量输入。四种不同兴奋性投射神经元之间存在类似的二分法。这些结果表明，长程海马体和丘脑传入系统在靶向特定的额皮质神经元时存在明显的偏向。此外，它们表明存在两个不同的局部微电路，控制不同输入如何控制额皮质信息处理。
