Wiedemann L M, D'Eustachio P, Kelley D E, Perry R P
Somat Cell Mol Genet. 1987 Jan;13(1):77-80. doi: 10.1007/BF02422301.
The mouse chromosomes bearing three functional ribosomal protein (rp) genes were identified by Southern blot analysis of DNA from a panel of mouse-hamster hybrid cell lines. Unique sequence intron probes were used to distinguish the functional rp genes from their multiple processed pseudogene counterparts. The genes specifying ribosomal proteins S16, L30, and L32 were found to be on chromosomes 7, 15, and 6, respectively. Since these functional rp genes are widely dispersed in the mouse genome, coordinate regulation of their transcriptional activity cannot be accomplished by a structural alteration of a single chromosomal region. Rather, it would have to involve interactions with sequences or structural motifs that are common to all three genes.
通过对一组小鼠 - 仓鼠杂交细胞系的DNA进行Southern印迹分析，鉴定出携带三个功能性核糖体蛋白（rp）基因的小鼠染色体。使用独特序列内含子探针将功能性rp基因与其多个加工后的假基因对应物区分开来。发现指定核糖体蛋白S16、L30和L32的基因分别位于第7、15和6号染色体上。由于这些功能性rp基因广泛分布在小鼠基因组中，它们转录活性的协调调控无法通过单个染色体区域的结构改变来实现。相反，它必须涉及与所有三个基因共有的序列或结构基序的相互作用。
