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创新型传染病疫苗平台：在 COVID-19 大流行背景下。

Innovative vaccine platforms against infectious diseases: Under the scope of the COVID-19 pandemic.

机构信息

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.

Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.

出版信息

Int J Pharm. 2021 Dec 15;610:121212. doi: 10.1016/j.ijpharm.2021.121212. Epub 2021 Oct 20.

DOI:10.1016/j.ijpharm.2021.121212
PMID:34687816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8527590/
Abstract

While classic vaccines have proved greatly efficacious in eliminating serious infectious diseases, innovative vaccine platforms open a new pathway to overcome dangerous pandemics via the development of safe and effective formulations. Such platforms play a key role either as antigen delivery systems or as immune-stimulators that induce both innate and adaptive immune responses. Liposomes or lipid nanoparticles, virus-like particles, nanoemulsions, polymeric or inorganic nanoparticles, as well as viral vectors, all belong to the nanoscale and are the main categories of innovative vaccines that are currently on the market or in clinical and preclinical phases. In this paper, we review the above formulations used in vaccinology and we discuss their connection with the development of safe and effective prophylactic vaccines against SARS-CoV-2.

摘要

虽然经典疫苗已被证明在消除严重传染病方面非常有效，但创新的疫苗平台通过开发安全有效的制剂，为克服危险的大流行病开辟了新途径。这些平台在作为抗原递送系统或作为诱导先天和适应性免疫反应的免疫刺激剂方面发挥着关键作用。脂质体或脂质纳米粒、类病毒颗粒、纳米乳液、聚合物或无机纳米粒以及病毒载体均属于纳米级，是目前市场上或临床前和临床阶段的创新疫苗的主要类别。在本文中，我们综述了疫苗学中使用的上述制剂，并讨论了它们与开发针对 SARS-CoV-2 的安全有效的预防性疫苗的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/6ca53c4246c6/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/759026818a63/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/54f2d466c4be/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/4d7656654756/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/457b3eb14f6a/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/6ca53c4246c6/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/759026818a63/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/54f2d466c4be/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/4d7656654756/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/457b3eb14f6a/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eef1/8527590/6ca53c4246c6/gr4_lrg.jpg

相似文献

[1]
Innovative vaccine platforms against infectious diseases: Under the scope of the COVID-19 pandemic.

Int J Pharm. 2021-12-15

[2]
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[3]
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[4]
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[5]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Nanotechnology-driven advances in intranasal vaccine delivery systems against infectious diseases.

Front Immunol. 2025-5-9

[2]
Editorial: New-generation vaccines and novel vaccinal strategies against infectious diseases of livestock, wild and companion animals.

Front Immunol. 2023-8-2

[3]
Bacterial Spore-Based Delivery System: 20 Years of a Versatile Approach for Innovative Vaccines.

Biomolecules. 2023-6-6

[4]
Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions.

Biomed Pharmacother. 2023-1

[5]
Lipid-based nanoparticles and RNA as innovative neuro-therapeutics.

Front Pharmacol. 2022-8-9

[6]
Analysis of the Impacts on the Psychological Changes of Chinese Returning College Students After the Outbreak of the 2019 Coronavirus Disease.

Front Public Health. 2022

本文引用的文献

[1]
Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines.

RSC Adv. 2018-5-4

[2]
Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine - United States, March-April 2021.

MMWR Morb Mortal Wkly Rep. 2021-5-7

[3]
Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

J Thromb Haemost. 2021-7

[4]
Ebola virus disease: current vaccine solutions.

Curr Opin Immunol. 2021-8

[5]
Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination.

N Engl J Med. 2021-6-10

[6]
Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.

N Engl J Med. 2021-6-3

[7]
Encapsulation state of messenger RNA inside lipid nanoparticles.

Biophys J. 2021-7-20

[8]
Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.

ACS Nano. 2021-4-27

[9]
Development of Pandemic Vaccines: ERVEBO Case Study.

Vaccines (Basel). 2021-2-25

[10]
Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.

MMWR Recomm Rep. 2021-1-8

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