Faculty of Dentistry, National University of Caaguazú, Coronel Oviedo, Paraguay.
Regional Institute for Health Research National University of Caaguazú, Coronel Oviedo, Paraguay,
Am J Dent. 2021 Oct;34(5):273-276.
To evaluate the effect of Carica papaya mouthrinse as an inhibitor of Streptococcus mutans.
This was a double blind (subject and evaluator) randomized controlled trial in 40 subjects distributed in two groups: Carica papaya mouthrinse intervention (n= 20) or chlorhexidine (n= 20). The antibacterial effect was determined by counting colony-forming units per milliliter (CFU/ml) of S. mutans in saliva sample cultures; taken both before mouthrinse, immediately after 10 minutes mouthrinsing, and 8 days after mouthrinsing. The data was statistically analyzed with Student's t-test (P ≤ 0.05).
The difference before and immediately after (10 minutes) use of Carica papaya mouthrinse was of 764 CFUs. After 8 days use the difference was 212 CFUs. For the control group (0.12% chlorhexidine) the difference before and immediately after use (10 minutes) was 683 CFUs. After 8 days use the difference was 455 CFU. When comparing between groups applying t-test, no statistical differences were found in the (CFU/ml) of S. mutans before and after 10 minutes mouthrinse (P= 0.8060), 10 minutes and 8 days after mouthrinsing (P= 0.7104) before and 8 days after mouthrinsing (P= 0.4419).
Carica papaya could be an alternative mouthrinse for the inhibition of Streptococcus mutans.
评价木瓜漱口水对变异链球菌的抑制作用。
这是一项双盲（受试对象和评估者）随机对照试验，共纳入 40 名受试对象，分为木瓜漱口水干预组（n=20）和洗必泰组（n=20）。通过检测唾液样本中变异链球菌的菌落形成单位（CFU/ml）来确定抗菌效果；分别在使用漱口水前、使用后 10 分钟和使用后 8 天采集唾液样本。使用 Student's t 检验对数据进行统计学分析（P≤0.05）。
使用木瓜漱口水前后即刻（10 分钟）的差异为 764 CFU/ml。使用 8 天后的差异为 212 CFU/ml。对照组（0.12%洗必泰）使用前后即刻（10 分钟）的差异为 683 CFU/ml。使用 8 天后的差异为 455 CFU/ml。应用 t 检验对两组进行比较，在使用前后即刻（10 分钟）、使用后 10 分钟与使用后 8 天的时间点，变异链球菌的 CFU/ml 均无统计学差异（P=0.8060）。
木瓜可能是一种替代漱口水，用于抑制变异链球菌。
