Myanmar Health Network Organization, Yangon, Myanmar.
Department of Public Health, Ministry of Health, NayPyiTaw, Myanmar.
Parasit Vectors. 2021 Oct 24;14(1):549. doi: 10.1186/s13071-021-05064-y.
Radical cure of the Plasmodium vivax latent liver stage is required to effectively manage vivax malaria. Targeted mass treatment with primaquine may be an effective mechanism for reducing reservoirs of the disease. Since community engagement and high coverage are essential for mass treatment programs, this study aimed to determine the acceptability of mass primaquine treatment in a targeted community in a northern Myanmar township.
A cross-sectional mixed-methods study was deployed among household leaders in July 2019. Face-to-face interviews using structured questionnaires and standardized qualitative guidelines were conducted to gather information. Descriptive and inferential statistics, including logistic regression models, were applied.
Among 609 study respondents, > 90% agreed to participate in an upcoming targeted mass primaquine treatment (TPT) program. Factors contributing to higher odds of acceptability of the program were older age [adjusted odds ratios (aOR): 2.38, 95% confidence intervals (CI) 1.08-8.96], secondary education level (aOR: 3.99, 95% CI 1.12-20.01), having good knowledge of malaria (aOR: 2.12, 95% CI 1.04-4.76), experiencing malaria within the family (aOR: 1.92, 95% CI 1.14-5.13), and believing eliminating malaria from the village is possible (aOR: 2.83, 95% CI 1.07-4.07). Furthermore, 50 community respondents, 6 midwives, and 4 public health staff (grade II) participated in the qualitative component of the study. Many thought that TPT seemed feasible and stressed that high coverage of underserved groups and health education are needed before commencing the activity.
Most respondents agreed to participate in the proposed mass treatment campaign. Older people with secondary education level and those who had experienced malaria within their families were most likely to report willingness to participate. These same individuals may be important in the community engagement process to increase community acceptance of the program.
根治间日疟原虫潜伏的肝脏阶段是有效管理间日疟的必要手段。以伯氨喹进行有针对性的大规模治疗可能是减少疾病储存的有效机制。由于社区参与和高覆盖率对于大规模治疗计划至关重要，因此本研究旨在确定在缅甸北部一个城镇的一个目标社区中大规模使用伯氨喹治疗的可接受性。
本研究采用了 2019 年 7 月在家庭负责人中开展的横断面混合方法研究。通过面对面访谈使用结构化问卷和标准化定性指南收集信息。应用描述性和推断性统计，包括逻辑回归模型。
在 609 名研究受访者中，超过 90%的人同意参加即将进行的有针对性的大规模伯氨喹治疗（TPT）计划。有助于提高对该计划接受程度的因素包括年龄较大（调整后的优势比[aOR]：2.38，95%置信区间[CI] 1.08-8.96）、中等教育程度（aOR：3.99，95%CI 1.12-20.01）、对疟疾有较好的了解（aOR：2.12，95%CI 1.04-4.76）、家庭中有疟疾经历（aOR：1.92，95%CI 1.14-5.13）和相信可以从村庄中消除疟疾（aOR：2.83，95%CI 1.07-4.07）。此外，50 名社区受访者、6 名助产士和 4 名二级公共卫生工作人员参加了研究的定性部分。许多人认为 TPT 似乎可行，并强调在开展活动之前需要覆盖服务不足的群体和开展健康教育。
大多数受访者同意参加拟议的大规模治疗活动。年龄较大、受过中等教育且家庭中有疟疾经历的人最有可能表示愿意参加。这些人可能在社区参与过程中非常重要，可以提高社区对该计划的接受程度。
