Myanmar Oxford Clinical Research Unit, Myanmar.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom.
J Infect Dis. 2019 Jun 5;220(1):100-104. doi: 10.1093/infdis/jiz052.
From 2003 through 2009, 687 of 2885 patients (23.8%) treated for Plasmodium falciparum malaria in clinical studies in Myanmar or on the Thailand-Myanmar border had recurrent Plasmodium vivax malaria within 63 days, compared with 18 of 429 patients (4.2%) from 2010 onward (risk ratio [RR], 0.176; 95% confidence interval, .112-.278; P < .0001). Corresponding data from 42 days of follow-up revealed that 820 of 3883 patients (21.1%) had recurrent P. vivax malaria before 2010, compared with 22 of 886 (2.5%) from 2010 onward (RR, 0.117; 95% CI, .077-.177; P < .0001). This 6-fold reduction suggests a recent decline in P. vivax transmission intensity and, thus, a substantial reduction in the proportion of individuals harboring hypnozoites.
从 2003 年到 2009 年，在缅甸或泰国-缅甸边境进行的临床试验中，2885 例恶性疟疾病例中，有 687 例（23.8%）在 63 天内出现了间日疟复发，而 2010 年以后的 429 例中，只有 18 例（4.2%）（风险比[RR]，0.176；95%置信区间，0.112-0.278；P < 0.0001）。42 天随访的相应数据显示，2010 年以前，3883 例患者中有 820 例（21.1%）出现间日疟复发，而 2010 年以后的 886 例中只有 22 例（2.5%）（RR，0.117；95%置信区间，0.077-0.177；P < 0.0001）。这种 6 倍的降幅表明，间日疟传播强度最近有所下降，因此携带休眠疟原虫的个体比例也大幅下降。
