间日疟原虫疟疾后复发率反映了先前的传播强度。
Plasmodium vivax Relapse Rates Following Plasmodium falciparum Malaria Reflect Previous Transmission Intensity.
机构信息
Myanmar Oxford Clinical Research Unit, Myanmar.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom.
出版信息
J Infect Dis. 2019 Jun 5;220(1):100-104. doi: 10.1093/infdis/jiz052.
From 2003 through 2009, 687 of 2885 patients (23.8%) treated for Plasmodium falciparum malaria in clinical studies in Myanmar or on the Thailand-Myanmar border had recurrent Plasmodium vivax malaria within 63 days, compared with 18 of 429 patients (4.2%) from 2010 onward (risk ratio [RR], 0.176; 95% confidence interval, .112-.278; P < .0001). Corresponding data from 42 days of follow-up revealed that 820 of 3883 patients (21.1%) had recurrent P. vivax malaria before 2010, compared with 22 of 886 (2.5%) from 2010 onward (RR, 0.117; 95% CI, .077-.177; P < .0001). This 6-fold reduction suggests a recent decline in P. vivax transmission intensity and, thus, a substantial reduction in the proportion of individuals harboring hypnozoites.
从 2003 年到 2009 年，在缅甸或泰国-缅甸边境进行的临床试验中，2885 例恶性疟疾病例中，有 687 例（23.8%）在 63 天内出现了间日疟复发，而 2010 年以后的 429 例中，只有 18 例（4.2%）（风险比[RR]，0.176；95%置信区间，0.112-0.278；P < 0.0001）。42 天随访的相应数据显示，2010 年以前，3883 例患者中有 820 例（21.1%）出现间日疟复发，而 2010 年以后的 886 例中只有 22 例（2.5%）（RR，0.117；95%置信区间，0.077-0.177；P < 0.0001）。这种 6 倍的降幅表明，间日疟传播强度最近有所下降，因此携带休眠疟原虫的个体比例也大幅下降。
Zotero 插件