Krog M P, Ekbom A, Nyström-Rosander C, Rudberg C R, Simonsson N O
Cancer. 1987 Apr 1;59(7):1358-61. doi: 10.1002/1097-0142(19870401)59:7<1358::aid-cncr2820590721>3.0.co;2-n.
A one-year prospective study to evaluate the use of central venous catheters in intensive treatment of patients with acute blood malignancies was performed. Forty-seven catheters in 29 patients were studied. In spite of thrombocytopenia in several patients, no severe bleeding episodes were observed. Five patients with agranulocytosis had episodes of bacterial growth in the blood. Four patients had a clinical infection in the subcutaneous tunnel of the catheter. Bacterial growths on the tips of the catheters were found in three cases. Six patients died during the observation period, none of these was in remission. One of these patients had a growth of coagulase negative staphylococci in the blood, and another on the tip of the catheter, without any other known source of infection. The use of central venous catheters facilitates patient care and minimizes discomfort. It is associated with acceptable complications, necessitating meticulous insertion techniques, and careful daily care on the ward or at home.
开展了一项为期一年的前瞻性研究，以评估中心静脉导管在急性血液系统恶性肿瘤患者强化治疗中的应用。对29例患者的47根导管进行了研究。尽管部分患者存在血小板减少症，但未观察到严重出血事件。5例粒细胞缺乏症患者出现血行细菌生长。4例患者在导管皮下隧道发生临床感染。3例在导管尖端发现细菌生长。6例患者在观察期内死亡，均未缓解。其中1例患者血中凝固酶阴性葡萄球菌生长，另1例导管尖端细菌生长，无其他已知感染源。中心静脉导管的使用便于患者护理并将不适降至最低。其并发症可接受，这就需要细致的置管技术以及在病房或家中进行仔细的日常护理。
