Won Sung-Min, Seo Min Ju, Kwon Min Ju, Park Kye Won, Yoon Jung-Hoon
Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, South Korea.
Front Microbiol. 2021 Oct 6;12:746601. doi: 10.3389/fmicb.2021.746601. eCollection 2021.
Effects of ADM14 on changes in lipid metabolism and fecal microbiota composition were studied in high-fat diet (HFD) mouse model. The mice were divided into three groups: normal diet (ND), high-fat diet (HD), and HFD plus ADM14 (HDA). Oral administration of ADM14 daily for 10weeks decreased body weight gain, fat tissue mass, and liver weight in mice and reduced the size of histologically stained liver adipocytes. In addition, serum total cholesterol, triglycerides, and blood glucose decreased significantly. ADM14 regulated the expression of genes related to lipid metabolism in epididymal adipose tissue and liver and induced changes in the composition of fecal microbiota, thereby improving energy harvests and changing metabolic disorder-related taxa. A significant decrease (<0.05) in the to ratio was found in the HDA group compared to the HD group, particularly due to the difference in the relative abundance of the between the two groups over 10weeks. Differences in proportions of some taxa reported to have correlation with obesity were also found between HD and HDA groups. These results suggest that ADM14 can have a positive effect on metabolic disorders such as obesity and fatty liver through effective regulation of host lipid metabolism and gut microbiota.
在高脂饮食（HFD）小鼠模型中研究了ADM14对脂质代谢变化和粪便微生物群组成的影响。小鼠被分为三组：正常饮食（ND）组、高脂饮食（HD）组和高脂饮食加ADM14（HDA）组。每天口服ADM14，持续10周，可降低小鼠的体重增加、脂肪组织质量和肝脏重量，并减小组织学染色的肝脏脂肪细胞大小。此外，血清总胆固醇、甘油三酯和血糖显著降低。ADM14调节附睾脂肪组织和肝脏中与脂质代谢相关基因的表达，并诱导粪便微生物群组成的变化，从而改善能量获取并改变与代谢紊乱相关的分类群。与HD组相比，HDA组的 与 比值显著降低（<0.05），特别是由于两组在10周内 的相对丰度存在差异。HD组和HDA组之间还发现了一些据报道与肥胖相关的分类群比例差异。这些结果表明，ADM14可以通过有效调节宿主脂质代谢和肠道微生物群，对肥胖和脂肪肝等代谢紊乱产生积极影响。
