抗 NMDAR 脑炎和抗 LGI1 脑炎的全面 B 细胞免疫反应谱分析。
Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis.
机构信息
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
出版信息
Front Immunol. 2021 Oct 7;12:717598. doi: 10.3389/fimmu.2021.717598. eCollection 2021.
Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) and anti-leucine-rich glioma-inactivated 1 encephalitis (anti-LGI1E) are the two most common types of antibody-mediated autoimmune encephalitis. We performed a comprehensive analysis of the B-cell immune repertoire in patients with anti-NMDARE ( = 7) and anti-LGI1E ( = 10) and healthy controls ( = 4). The results revealed the presence of many common clones between patients with these two types of autoimmune encephalitis, which were mostly class-switched. Additionally, many differences were found among the anti-NMDARE, anti-LGI1E, and healthy control groups, including the diversity of the B-cell immune repertoire and gene usage preference. These findings suggest that the same adaptive immune responses occur in patients with anti-NMDARE and anti-LGI1E, which deserves further exploration.
抗 N-甲基-D-天冬氨酸受体脑炎（anti-NMDARE）和抗亮氨酸丰富的胶质瘤失活 1 型脑炎（anti-LGI1E）是两种最常见的抗体介导自身免疫性脑炎。我们对抗 NMDARE（=7）、抗 LGI1E（=10）患者和健康对照者（=4）的 B 细胞免疫受体库进行了全面分析。结果表明，这两种自身免疫性脑炎患者之间存在许多共同的克隆，这些克隆大多发生了类别转换。此外，在抗 NMDARE、抗 LGI1E 和健康对照组之间还发现了许多差异，包括 B 细胞免疫受体库的多样性和基因使用偏好。这些发现提示抗 NMDARE 和抗 LGI1E 患者存在相同的适应性免疫反应，值得进一步探索。
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