Vu Tri, Tang Yuqi, Li Mucong, Sankin Georgii, Tang Shanshan, Chen Shigao, Zhong Pei, Yao Junjie
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Biomed Opt Express. 2021 Aug 10;12(9):5489-5498. doi: 10.1364/BOE.426660. eCollection 2021 Sep 1.
Mechanical high-intensity focused ultrasound (HIFU) has been used for cancer treatment and drug delivery. Existing monitoring methods for mechanical HIFU therapies such as MRI and ultrasound imaging often suffer from high cost, poor spatial-temporal resolution, and/or low sensitivity to tissue's hemodynamic changes. Evaluating vascular injury during mechanical HIFU treatment, therefore, remains challenging. Photoacoustic computed tomography (PACT) is a promising tool to meet this need. Intrinsically sensitive to optical absorption, PACT provides high-resolution imaging of blood vessels using hemoglobin as the endogenous contrast. In this study, we have developed an integrated HIFU-PACT system for detecting vascular rupture in mechanical HIFU treatment. We have demonstrated singular value decomposition for enhancing hemorrhage detection. We have validated the HIFU-PACT performance on phantoms and animal tumor models. We expect that PACT-HIFU will find practical applications in oncology research using small animal models.
机械高强度聚焦超声（HIFU）已被用于癌症治疗和药物递送。现有的机械HIFU治疗监测方法，如磁共振成像（MRI）和超声成像，常常存在成本高、时空分辨率差和/或对组织血流动力学变化敏感性低的问题。因此，评估机械HIFU治疗期间的血管损伤仍然具有挑战性。光声计算机断层扫描（PACT）是满足这一需求的一种很有前景的工具。PACT对光吸收具有内在敏感性，利用血红蛋白作为内源性对比剂提供血管的高分辨率成像。在本研究中，我们开发了一种集成的HIFU-PACT系统，用于检测机械HIFU治疗中的血管破裂。我们展示了用于增强出血检测的奇异值分解。我们已经在体模和动物肿瘤模型上验证了HIFU-PACT的性能。我们期望PACT-HIFU将在使用小动物模型的肿瘤学研究中找到实际应用。
