Goo Hyeyoon, Mo SangJoon, Park Hyeong Ju, Lee Min Young, Ahn Jin-Chul
Department of Medical Laser, Graduate School of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Medical Laser Research Center, Dankook University, Cheonan 31116, Republic of Korea.
Biomed Opt Express. 2021 Aug 13;12(9):5583-5596. doi: 10.1364/BOE.427205. eCollection 2021 Sep 1.
Photobiomodulation (PBM) is attracting increased attention in the fields of dermatology and cosmetics. PBM with a variety of light parameters has been used widely in skin care, but can cause certain types of unwanted cells to proliferate in the skin; this can lead to skin tumors, such as papillomas and cancers. We constructed a mouse model of human skin tumors using DMBA as an initiator and TPA as a promoter, and confirmed that LEDs with a wavelength of 642 nm (red light) increased tumor size, epidermal thickness, and systemic proinflammatory cytokine levels. These results indicated that skin tumor cell proliferation may result from the use of 642 nm LEDs, suggesting the need for regulation of skin care based on LED light therapy.
光生物调节作用（PBM）在皮肤病学和化妆品领域正吸引着越来越多的关注。具有各种光参数的PBM已广泛应用于皮肤护理，但可能会导致某些类型的有害细胞在皮肤中增殖；这可能会引发皮肤肿瘤，如乳头状瘤和癌症。我们使用二甲基苯并蒽（DMBA）作为引发剂、佛波酯（TPA）作为促癌剂构建了人类皮肤肿瘤小鼠模型，并证实波长为642nm的发光二极管（LED，红光）会增加肿瘤大小、表皮厚度和全身促炎细胞因子水平。这些结果表明，使用642nm的LED可能会导致皮肤肿瘤细胞增殖，这表明需要对基于LED光疗法的皮肤护理进行规范。
