Feng Zefeng, Wang Peipei, Song Yang, Wang Haiyang, Jin Zhiliang, Xiong Daxi
School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China.
Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu 215163, China.
Biomed Opt Express. 2023 Mar 30;14(4):1800-1817. doi: 10.1364/BOE.484865. eCollection 2023 Apr 1.
LED-based photobiomodulation (LED-PBM) for the treatment of knee osteoarthritis (KOA) is a promising technology. However, the light dose at the targeted tissue, which dominates the phototherapy effectiveness, is difficult to measure. This paper studied the dosimetric issues in the phototherapy of KOA by developing an optical model of the knee and performing Monte Carlo (MC) simulation. The model was validated by the tissue phantom and knee experiments. In the study, we investigated the effect of luminous characteristics of the light source, such as divergence angle, wavelength and irradiation position, on the treatment doses for PBM. The result showed that the divergence angle and the wavelength of the light source have a significant impact on the treatment doses. The optimal irradiation location was on both sides of the patella, where the largest dose could reach the articular cartilage. This optical model can be used to determine the key parameters in phototherapy and help the phototherapy of KOA patients.
基于发光二极管的光生物调节疗法（LED-PBM）用于治疗膝关节骨关节炎（KOA）是一项很有前景的技术。然而，主导光疗效果的靶向组织处的光剂量难以测量。本文通过建立膝关节光学模型并进行蒙特卡洛（MC）模拟，研究了KOA光疗中的剂量测定问题。该模型通过组织模型和膝关节实验进行了验证。在研究中，我们研究了光源的发光特性，如发散角、波长和照射位置，对PBM治疗剂量的影响。结果表明，光源的发散角和波长对治疗剂量有显著影响。最佳照射位置在髌骨两侧，此处最大剂量可到达关节软骨。该光学模型可用于确定光疗中的关键参数，并有助于KOA患者的光疗。
