Pergolizzi Joseph, Breve Frank, Magnusson Peter, Nalamasu Rohit, LeQuang Jo Ann K, Varrassi Giustino
Cardiology, Native Cardio, Inc., Naples, USA.
Department of Pharmacy, Temple University, Philadelphia, USA.
Cureus. 2021 Sep 18;13(9):e18084. doi: 10.7759/cureus.18084. eCollection 2021 Sep.
Opioid toxicity can result in life-threatening respiratory depression. Opioid-overdose mortality in the United States is high and increasing, but it is difficult to determine what proportion of those deaths might actually be suicides. The exact number of Americans who died of an opioid overdose but whose deaths might be classified as suicide remains unknown. It is important to differentiate between those who take opioids with the deliberate and unequivocal objective of committing suicide, that is, those with active intent, from those with passive intent. The passive-intent group understands the risks of opioid consumption and takes dangerous amounts, but with a more ambiguous attitude toward suicide. Thus, among decedents of opioid overdose, a large population dies by accident, whereas a small population dies intending to commit suicide; but between them exists a sub-population with equivocal intentions, waxing and waning between their desire to live and the carelessness about death. There may be a passive as well as active intent to commit suicide, but less is known about the passive motivation. It is important for public health efforts aimed at reducing both suicides and opioid-use disorder to better understand the range of motivations behind opioid-related suicides and how to combat them.
阿片类药物中毒可导致危及生命的呼吸抑制。美国阿片类药物过量致死率很高且呈上升趋势,但很难确定这些死亡中有多大比例实际上可能是自杀。死于阿片类药物过量但可能被归类为自杀的美国人的确切人数仍然未知。区分那些故意且明确以自杀为目的服用阿片类药物的人(即有主动意图的人)和有被动意图的人很重要。被动意图组了解服用阿片类药物的风险并服用危险剂量,但对自杀的态度较为模糊。因此,在阿片类药物过量致死的死者中,很大一部分是意外死亡,而一小部分是自杀身亡;但在他们之间存在一个意图模糊的亚群体,在求生欲望和对死亡的漠视之间摇摆不定。可能存在主动和被动的自杀意图,但对被动动机的了解较少。对于旨在减少自杀和阿片类药物使用障碍的公共卫生努力而言,更好地了解阿片类药物相关自杀背后的动机范围以及如何应对这些动机非常重要。