Kumar Jitesh, Makheja Kainat, Rahul Fnu, Kumar Suneel, Kumar Manoj, Chand Momal, Kammawal Yasir, Khalid Dua, Jahangir Maha, Bachani Parkash
Internal Medicine, Ghulam Muhammad Mahar Medical College, Sukkur, PAK.
Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK.
Cureus. 2021 Sep 20;13(9):e18131. doi: 10.7759/cureus.18131. eCollection 2021 Sep.
Recent research has observed the ability of coronavirus disease 2019 (COVID-19) to spread in the brain from the respiratory system. The associated neurological disorder includes encephalopathies, inflammatory syndromes, stroke, peripheral neuropathies, and various other central nervous system disorders. This study aims to highlight the long-term neurological sequelae in patients with COVID-19 disease.
This long-term study was carried out in the COVID-19 unit of a tertiary care hospital in Pakistan from July 2020 to July 2021. After obtaining informed consent, we enrolled 1000 patients who recovered from COVID-19 and were discharged. The participants were followed up after 30 and 90 days.
At the time of enrollment, there were 602 (60.2%) males and 398 (39.8%) females. The most common neurological symptom on 30-day follow-up was headache (8.8%), followed by insomnia. The most common neurological symptom on day 90 follow-up was insomnia (5.07%), followed by an altered sense of smell (3.3%).
COVID-19 tends to produce a wide range of neurological symptoms, ranging from headache to anosmia to increased risk of stroke, that complicates clinical management. Potential neurologic effects and drug interactions have been reported secondary to the medications used to treat COVID-19. In light of the aforementioned facts, COVID-19 could potentially have a long-term effect on the brain. Therefore, it is important that the clinicians must be aware of the potential neurologic complications. Lastly, proper follow-up is recommended that would aid in timely recognition and management of the neurological disorder.
最近的研究观察到2019冠状病毒病（COVID-19）能够从呼吸系统扩散至大脑。相关的神经系统疾病包括脑病、炎症综合征、中风、周围神经病变以及各种其他中枢神经系统疾病。本研究旨在突出COVID-19患者的长期神经后遗症。
这项长期研究于2020年7月至2021年7月在巴基斯坦一家三级护理医院的COVID-19病房进行。在获得知情同意后，我们纳入了1000名从COVID-19康复并出院的患者。在30天和90天后对参与者进行随访。
入组时，男性有602名（60.2%），女性有398名（39.8%）。30天随访时最常见的神经症状是头痛（8.8%），其次是失眠。90天随访时最常见的神经症状是失眠（5.07%），其次是嗅觉改变（3.3%）。
COVID-19往往会产生广泛的神经症状，从头痛到嗅觉丧失再到中风风险增加，这使临床管理变得复杂。据报道，用于治疗COVID-19的药物会引发潜在的神经效应和药物相互作用。鉴于上述事实，COVID-19可能会对大脑产生长期影响。因此，临床医生必须意识到潜在的神经并发症，这一点很重要。最后，建议进行适当的随访，这将有助于及时识别和管理神经系统疾病。
