Trott Mike, Driscoll Robin, Pardhan Shahina
Vision and Eye Research Institute, Anglia Ruskin University, Cambridge, United Kingdom.
Centre for Public Health, Queen's University Belfast, Belfast, United Kingdom.
Front Med (Lausanne). 2022 Aug 25;9:980253. doi: 10.3389/fmed.2022.980253. eCollection 2022.
Post-COVID syndrome can be defined as symptoms of COVID-19 that persist for longer than 12 weeks, with several studies reporting persistent symptoms relating to the sensory organs (eyes, ears, and nose). The aim of this systematic review was to examine the prevalence of persistent anosmia, hyposmia, ageusia, and hypogeusia, as well as eye/vision and ear/hearing related long-COVID symptoms. Authors searched the electronic databases from inception to November 2021. Search terms included words related to long-COVID, smell, taste, eyes/vision, and ears/hearing, with all observational study designs being included. A random effects meta-analysis was undertaken, calculating the prevalence proportions of anosmia, hyposmia, ageusia, and hypogeusia, respectively. From the initial pool, 21 studies met the inclusion criteria (total 4,707; median per study 125; median age = 49.8; median percentage female = 59.2%) and 14 were included in the meta-analysis The prevalence of anosmia was 12.2% (95% CI 7.7-16.6%), hyposmia 29.9% (95% CI 19.9-40%), ageusia 11.7% (95% CI 6.1-17.3%), and hypogeusia 31.2% (95% 16.4-46.1%). Several eye/vision and ear/hearing symptoms were also reported. Considering that changes in the sensory organs are associated with decreases in quality of life, future research should examine the etiology behind the persistent symptoms.
[www.crd.york.ac.uk/prospero], identifier [CRD42021292804].
新冠后综合征可定义为新冠病毒感染症状持续超过12周，多项研究报告了与感觉器官（眼睛、耳朵和鼻子）相关的持续症状。本系统评价的目的是研究持续性嗅觉丧失、嗅觉减退、味觉丧失和味觉减退的患病率，以及与眼睛/视力和耳朵/听力相关的新冠后长期症状。作者检索了自数据库建立至2021年11月的电子数据库。检索词包括与新冠后长期症状、嗅觉、味觉、眼睛/视力和耳朵/听力相关的词汇，纳入所有观察性研究设计。进行了随机效应荟萃分析，分别计算嗅觉丧失、嗅觉减退、味觉丧失和味觉减退的患病率。从最初的文献库中，21项研究符合纳入标准（共4707例；每项研究中位数为125例；年龄中位数=49.8岁；女性中位数百分比=59.2%），14项纳入荟萃分析。嗅觉丧失的患病率为12.2%（95%CI 7.7-16.6%），嗅觉减退为29.9%（95%CI 19.9-40%），味觉丧失为11.7%（95%CI 6.1-17.3%），味觉减退为31.2%（95%CI 16.4-46.1%）。还报告了一些眼睛/视力和耳朵/听力症状。鉴于感觉器官的变化与生活质量下降有关，未来的研究应探讨这些持续症状背后的病因。
