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新冠病毒感染后神经系统并发症;一项荟萃分析。

Post COVID-19 neurological complications; a meta-analysis.

作者信息

Ahmed Jaafar Omer, Ahmad Shwan Abdubakr, Hassan Marwan Nasih, Kakamad Fahmi H, Salih Rawezh Q, Abdulla Berwn A, Rahim Fattah Fattah Hama, Mohammed Shvan H, Ali Razhan K, Salih Abdulwahid M

机构信息

Kscien Organization, Hamdi Str, Azadi Mall, Sulaimani, Kurdistan, Iraq.

Mental Health Treatment Center, Madam Mitterrand Street, Sulaimani, Iraq.

出版信息

Ann Med Surg (Lond). 2022 Apr;76:103440. doi: 10.1016/j.amsu.2022.103440. Epub 2022 Mar 3.

Abstract

INTRODUCTION

Despite numerous studies regarding neurological manifestations and complications of COVID-19, only a few cases of neurological consequences following complete recovery from SARS-CoV-2 infection have been described.

OBJECTIVES

The current study aims to present a quantitative meta-analysis of published studies regarding the post-infectious neurological complications of COVID-19.

DATA SOURCES

The Web of Science, PubMed, MEDLINE on OVID, and Google scholar were searched for English-language researches published after January 1, 2020.

RESULT

The review of the literature revealed 60 cases - of which 40 (66.7%) cases were male, and 18 (30%) were female. The average age was 44.95 years. Overall, 17 (28.3%) patients had comorbid conditions. Twenty-four (40%) patients were hospitalized during an active COVID-19 infection. The average interval from the COVID-19 infection to the onset of neurological sequelae was 33.2 days. Guillain-Barre syndrome was the most commonly reported neurological condition (15, 25%).

CONCLUSION

Despite recovery from acute infection, the pandemic highlights the significance of ongoing, comprehensive follow-up of all COVID-19 patients - even those initially were believed to be asymptomatic.

摘要

引言

尽管有大量关于新冠病毒病(COVID-19)神经学表现和并发症的研究,但仅有少数几例在从严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染完全康复后出现神经学后果的病例被描述。

目的

本研究旨在对已发表的关于COVID-19感染后神经并发症的研究进行定量荟萃分析。

数据来源

检索了科学网、PubMed、OVID上的MEDLINE以及谷歌学术,以查找2020年1月1日之后发表的英文研究。

结果

文献综述发现了60例病例,其中40例(66.7%)为男性,18例(30%)为女性。平均年龄为44.95岁。总体而言,17例(28.3%)患者有合并症。24例(40%)患者在COVID-19感染活跃期住院。从COVID-19感染到神经后遗症发作的平均间隔时间为33.2天。吉兰-巴雷综合征是最常报告的神经疾病(15例,25%)。

结论

尽管从急性感染中康复,但这场大流行凸显了对所有COVID-19患者进行持续、全面随访的重要性,即使是那些最初被认为无症状的患者。

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