小细胞肺癌骨转移的诊断和预后列线图。
Diagnostic and prognostic nomograms for bone metastasis in small cell lung cancer.
机构信息
Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Oncology, 105862First Hospital of Shanxi Medical University, First Hospital of Shanxi Medical University, Taiyuan, China.
出版信息
J Int Med Res. 2021 Oct;49(10):3000605211050735. doi: 10.1177/03000605211050735.
OBJECTIVE
Patients with bone metastasis (BM) of small cell lung cancer (SCLC) have a poor prognosis. We aimed to identify predictors and prognostic factors in patients with BM of SCLC and construct nomograms to predict BM.
METHODS
We retrospectively analyzed 18,187 cases from the Surveillance, Epidemiology, and End Results database reported between 2010 and 2016. Differences in overall survival (OS) and cancer-specific survival (CSS) were evaluated after propensity score matching. Independent predictors for BM and prognostic factors for patients with BM of SCLC were determined using univariate and multivariate regression analyses. Two nomograms were constructed and evaluated using C-statistics.
RESULTS
BM was observed in 4014 (22.07%) patients. Kaplan-Meier survival analysis revealed significant differences between BM and non-BM groups. The median OS for patients with and without BM was 6 and 7 months, respectively. The median CSS for patients with and without BM was 9 and 13 months, respectively. Age, sex, tumor size, N stage, chemotherapy, surgery, radiotherapy, and liver/brain/lung metastases were related to BM and independent prognostic factors for OS and CSS. Diagnostic and prognostic nomograms were generated.
CONCLUSION
Our nomograms predicted the incidence of BM and the 5-month survival rate of patients with SCLC and BM.
目的
患有小细胞肺癌（SCLC）骨转移（BM）的患者预后较差。我们旨在确定 SCLC 伴 BM 患者的预测指标和预后因素，并构建列线图以预测 BM。
方法
我们回顾性分析了 2010 年至 2016 年期间来自 Surveillance, Epidemiology, and End Results 数据库的 18187 例病例。通过倾向评分匹配评估总生存期（OS）和癌症特异性生存期（CSS）的差异。使用单因素和多因素回归分析确定 BM 的独立预测因素和 SCLC 伴 BM 患者的预后因素。构建并使用 C 统计量评估了两个列线图。
结果
4014 例（22.07%）患者发生 BM。Kaplan-Meier 生存分析显示 BM 组与非 BM 组之间存在显著差异。有 BM 和无 BM 的患者的中位 OS 分别为 6 个月和 7 个月。有 BM 和无 BM 的患者的中位 CSS 分别为 9 个月和 13 个月。年龄、性别、肿瘤大小、N 分期、化疗、手术、放疗以及肝/脑/肺转移与 BM 相关，是 OS 和 CSS 的独立预后因素。生成了诊断和预后列线图。
结论
我们的列线图预测了 SCLC 和 SCLC 伴 BM 患者的 BM 发生率和 5 个月生存率。
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