Ware Ashley L, Shukla Ayushi, Guo Sunny, Onicas Adrian, Geeraert Bryce L, Goodyear Bradley G, Yeates Keith Owen, Lebel Catherine
Department of Psychology, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada.
Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Brain Imaging Behav. 2022 Jun;16(3):991-1002. doi: 10.1007/s11682-021-00582-w. Epub 2021 Oct 25.
Motion can compromise image quality and confound results, especially in pediatric research. This study evaluated qualitative and quantitative approaches to motion artifacts detection and correction, and whether motion artifacts relate to injury history, age, or sex in children with mild traumatic brain injury or orthopedic injury relative to typically developing children. The concordance between qualitative and quantitative motion ratings was also examined. Children aged 8-16 years with mild traumatic brain injury (n = 141) or orthopedic injury (n = 73) were recruited from the emergency department and completed an MRI scan roughly 2 weeks post-injury. Typically developing children (n = 41) completed a single MRI scan. T1- and diffusion-weighted images were visually inspected and rated for motion artifacts by trained examiners. Quantitative estimates of motion artifacts were derived from FreeSurfer and FSL. Age (younger > older) and sex (boys > girls) were significantly associated with motion artifacts on both T1- and diffusion-weighted images. Children with mild traumatic brain or orthopedic injury had significantly more motion-corrupted diffusion-weighted volumes than typically developing children, but mild traumatic brain injury and orthopedic injury groups did not differ from each other. The exclusion of motion-corrupted volumes did not significantly change diffusion tensor imaging metrics. Results indicate that automated quantitative estimates of motion artifacts, which are less labour-intensive than manual methods, are appropriate. Results have implications for the reliability of structural MRI research and highlight the importance of considering motion artifacts in studies of pediatric mild traumatic brain injury.
运动可能会影响图像质量并混淆结果，尤其是在儿科研究中。本研究评估了运动伪影检测和校正的定性和定量方法，以及运动伪影是否与轻度创伤性脑损伤或骨科损伤儿童相对于正常发育儿童的损伤史、年龄或性别有关。还检查了定性和定量运动评级之间的一致性。从急诊科招募了8至16岁患有轻度创伤性脑损伤（n = 141）或骨科损伤（n = 73）的儿童，并在受伤后约2周完成了MRI扫描。正常发育儿童（n = 41）完成了一次MRI扫描。由训练有素的检查人员对T1加权和扩散加权图像进行视觉检查并对运动伪影进行评级。运动伪影的定量估计来自FreeSurfer和FSL。年龄（ younger > older）和性别（ boys > girls）在T1加权和扩散加权图像上均与运动伪影显著相关。患有轻度创伤性脑损伤或骨科损伤的儿童的扩散加权体积受运动影响的程度明显高于正常发育儿童，但轻度创伤性脑损伤组和骨科损伤组之间没有差异。排除受运动影响的体积并没有显著改变扩散张量成像指标。结果表明，与手动方法相比劳动强度较小的运动伪影自动定量估计是合适的。研究结果对结构MRI研究的可靠性具有启示意义，并突出了在儿科轻度创伤性脑损伤研究中考虑运动伪影的重要性。
