Eriguchi M, Carré-Llopis A, Orbach-Arbouys S, Escribano J
J Natl Cancer Inst. 1987 Mar;78(3):519-25.
Individual lesions in the pancreas and the presence of fetal acinar antigens along with carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine (CAS: 60599-38-4) were studied by open biopsy in 16 Syrian golden hamsters 13, 22, and 40 weeks after initiation of treatment. At 13 weeks, cystadenoma and regular ductal hyperplasia were noted in 3 animals and 1 animal, respectively. Staining for fetal acinar antigens in the pancreas was found in 69% of the hamsters. At 22 weeks, cystadenoma and hyperplastic ducts were common (60 and 53%), and 3 hamsters developed pancreatic adenocarcinoma. Fetal acinar antigens persisted in the acini and extended to irregular hyperplastic ducts and tumor cells. At 40 weeks, ductal proliferation was the main lesion in all pancreatic tissue, and 9 animals had adenocarcinoma. Acinar antigens were found in the remaining acini, in irregular hyperplastic ducts, and in tumor cells. Thus, once reexpressed, fetal acinar antigens persist in pancreatic lesions and pancreatic carcinomas in the hamster.
通过对16只叙利亚金仓鼠在开始治疗后13周、22周和40周进行开放性活检，研究了胰腺中的单个病变以及胎儿腺泡抗原的存在情况，以及由N-亚硝基双（2-氧代丙基）胺（CAS：60599-38-4）诱导的致癌作用。在13周时，分别在3只动物和1只动物中发现了囊腺瘤和规则的导管增生。在69%的仓鼠中发现胰腺中有胎儿腺泡抗原染色。在22周时，囊腺瘤和增生性导管很常见（分别为60%和53%），3只仓鼠发生了胰腺腺癌。胎儿腺泡抗原在腺泡中持续存在，并延伸至不规则增生的导管和肿瘤细胞。在40周时，导管增生是所有胰腺组织中的主要病变，9只动物患有腺癌。在剩余的腺泡、不规则增生的导管和肿瘤细胞中发现了腺泡抗原。因此，一旦重新表达，胎儿腺泡抗原就会在仓鼠的胰腺病变和胰腺癌中持续存在。
