Department of Bioelectronics and Biosensors, Alagappa University, Karaikudi, India.
Department of Botany, Alagappa University, Karaikudi, India.
IET Nanobiotechnol. 2021 Jun;15(4):441-454. doi: 10.1049/nbt2.12055. Epub 2021 May 11.
The sustainable development of natural polysaccharide-based hybrid composites is highly important for the effective replacement of metal nanoparticles in diverse applications. Here, polypyrrole nanotubes (PPyNTs) were embedded on the surface of aminated gum acacia (AGA) to produce ecofriendly nanocomposites for biomedical applications. The morphology of a PPyNT-enhanced AGA (PPyNT@AGA) hybrid nanocomposite was studied by scanning electron microscopy and transmission electron microscopy and their affirmed interactions were characterised by X-ray diffraction, Raman, Fourier transform-infrared and UV-visible spectroscopy. Interestingly, the prepared PPyNT@AGA nanocomposite exhibited 90% biofilm inhibition against gram-negative Pseudomonas aeruginosa, gram-positive Streptococcus pneumoniae and fungal strain Candida albicans with promising antimicrobial performance. This study establishes the good inhibition of a PPyNT@AGA hybrid composite against various microorganisms. The stability of the nanocomposite coupled with antimicrobial activity enables an effective strategy for diagnosing and controlling pathogens.
基于天然多糖的杂化复合材料的可持续发展对于在各种应用中有效替代金属纳米粒子至关重要。在这里，将聚吡咯纳米管（PPyNTs）嵌入氨化金合欢胶（AGA）的表面，以生产用于生物医学应用的环保纳米复合材料。通过扫描电子显微镜和透射电子显微镜研究了PPyNT 增强 AGA（PPyNT@AGA）杂化纳米复合材料的形态，通过 X 射线衍射、拉曼、傅里叶变换红外和紫外可见光谱证实了它们的相互作用。有趣的是，所制备的 PPyNT@AGA 纳米复合材料对革兰氏阴性铜绿假单胞菌、革兰氏阳性肺炎链球菌和真菌白色念珠菌表现出 90%的生物膜抑制作用，具有良好的抗菌性能。本研究确立了 PPyNT@AGA 杂化复合材料对各种微生物的良好抑制作用。纳米复合材料的稳定性与抗菌活性相结合，为诊断和控制病原体提供了一种有效的策略。
