Trachoma Control Program, The Carter Center, Atlanta, Georgia.
Trachoma Control Program, The Carter Center, Addis Ababa, Ethiopia.
Am J Trop Med Hyg. 2021 Oct 25;106(1):62-65. doi: 10.4269/ajtmh.21-0873.
Infants ages < 6 months do not receive azithromycin as part of trachoma control and thus may serve as an infection reservoir in persistently endemic districts. The aim of this study was to determine the population-based Chlamydia trachomatis infection prevalence and infectious load among infants ages 1-12 months in persistently trachoma endemic districts in Amhara, Ethiopia. Across six districts, 475 infants were enumerated, and of these 464 (97.7%) were swabbed for infection testing. The C. trachomatis infection prevalence in the study area among infants was 0.2% (95% CI: 0.0-1.5). Among children ages 0-5 years positive for C. trachomatis, the median load was 31 elementary bodies (EB) (Inter quartile range: 7-244 EB), and the infection-positive infant had a load of 7,755 EB. While it is worth reconsidering azithromycin treatment recommendations for the potential mortality benefits, these results do not support lowering the treatment age for trachoma control.
年龄<6 个月的婴儿不在沙眼控制方案中接受阿奇霉素治疗，因此可能成为持续流行地区的感染源。本研究旨在确定在埃塞俄比亚阿姆哈拉地区持续流行沙眼的地区，1-12 月龄婴儿的人群中沙眼衣原体感染的流行率和感染负荷。在六个区，对 475 名婴儿进行了计数，其中 464 名（97.7%）进行了拭子检测以进行感染检测。研究区域中婴儿的沙眼衣原体感染率为 0.2%（95%CI：0.0-1.5）。在沙眼衣原体阳性的 0-5 岁儿童中，中位负荷为 31 个基本体（EB）（四分位间距：7-244 EB），感染阳性婴儿的负荷为 7755 EB。虽然有必要重新考虑阿奇霉素治疗建议以获得潜在的生存获益，但这些结果并不支持降低沙眼控制的治疗年龄。
