De Lerma Barbaro Andrea, Palano Maria Teresa, Cucchiara Martina, Gallazzi Matteo, Mortara Lorenzo, Bruno Antonino
Laboratory of Comparative Physiopathology, Department of Biotechnology and Life Sciences, University of Insubria, 21100 Varese, Italy.
Laboratory of Innate Immunity, Unit of Molecular Pathology, Biochemistry and Immunology, IRCCS MultiMedica, 20100 Milan, Italy.
Vaccines (Basel). 2021 Oct 14;9(10):1178. doi: 10.3390/vaccines9101178.
Leukocytes often undergo rapid changes in cell phenotype, for example, from a resting to an activated state, which places significant metabolic demands on the cell. These rapid changes in metabolic demand need to be tightly regulated to support immune cell effector functions during the initiation and downregulation of an immune response. Prospects for implementing cancer immunotherapy also rest on the idea of optimizing the metabolic profile of immune cell effectors. Here, we examine this issue by focusing on neutrophils and NK cells as cells of increasing interest in cancer immunology and tumor immunometabolism, because they can be targeted or, in the case of NK, used as effectors in immunotherapy. In addition, neutrophils and NK cells have been shown to functionally interact. In the case of neutrophils, we also extended our interest to polymorphonuclear MDSC (PMN-MDSCs), since the granulocytic subset of MDSCs share many phenotypes and are functionally similar to pro-tumor neutrophils. Finally, we reviewed relevant strategies to target tumor metabolism, focusing on neutrophils and NK cells.
白细胞经常经历细胞表型的快速变化，例如从静止状态转变为激活状态，这对细胞提出了显著的代谢需求。代谢需求的这些快速变化需要得到严格调控，以在免疫反应的启动和下调过程中支持免疫细胞效应功能。实施癌症免疫疗法的前景也取决于优化免疫细胞效应器代谢特征的理念。在此，我们通过关注中性粒细胞和自然杀伤（NK）细胞来研究这个问题，这两种细胞在癌症免疫学和肿瘤免疫代谢中越来越受关注，因为它们可以作为靶点，或者在NK细胞的情况下，用作免疫疗法的效应器。此外，中性粒细胞和NK细胞已被证明在功能上相互作用。对于中性粒细胞，我们还将兴趣扩展到多形核髓源性抑制细胞（PMN-MDSC），因为MDSC的粒细胞亚群具有许多相同的表型，并且在功能上与促肿瘤中性粒细胞相似。最后，我们综述了针对肿瘤代谢的相关策略，重点关注中性粒细胞和NK细胞。
