Department of Cellular Biology, Histology and Pharmacology, Faculty of Health Sciences, University of Valladolid, Campus of Soria, 42004 Soria, Spain.
Neurobiology Research Group, Faculty of Medicine, University of Valladolid, 47005 Valladolid, Spain.
Viruses. 2021 Sep 24;13(10):1916. doi: 10.3390/v13101916.
Coronavirus disease 2019 (COVID-19) is a multisystem disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that primarily causes respiratory symptoms. However, an increasing number of cutaneous manifestations associated with this disease have been reported. The aim of this study is to analyze the scientific literature on cutaneous manifestations associated with SARS-CoV-2 by means of a narrative literature review until June 2021. The search was conducted in the following electronic databases: Medline (PubMed), SciELO, and Cochrane Library Plus. The most common cutaneous manifestations in patients with COVID-19 are vesicular eruptions, petechial/purpuric rashes, acral lesions, liveoid lesions, urticarial rash, and maculopapular-erythematous rash. These manifestations may be the first presenting symptoms of SARS-CoV-2 infection, as is the case with acral lesions, vesicular eruptions, and urticaria. In relation to severity, the presence of liveoid lesions may be associated with a more severe course of the disease. Treatment used for dermatological lesions includes therapy with anticoagulants, corticosteroids, and antihistamines. Knowledge of the dermatologic manifestations associated with SARS-CoV-2 contributes to the diagnosis of COVID-19 in patients with skin lesions associated with respiratory symptoms or in asymptomatic patients. In addition, understanding the dermatologic lesions associated with COVID-19 could be useful to establish a personalized care plan.
2019 年冠状病毒病（COVID-19）是一种由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的多系统疾病，主要引起呼吸道症状。然而，越来越多的与这种疾病相关的皮肤表现已被报道。本研究旨在通过叙述性文献综述分析截至 2021 年 6 月与 SARS-CoV-2 相关的皮肤表现的科学文献。检索在以下电子数据库中进行：Medline（PubMed）、SciELO 和 Cochrane Library Plus。COVID-19 患者最常见的皮肤表现是水疱性皮疹、瘀点/瘀斑性皮疹、肢端病变、类狼疮病变、荨麻疹和斑丘疹-红斑性皮疹。这些表现可能是 SARS-CoV-2 感染的首发症状，如肢端病变、水疱性皮疹和荨麻疹。关于严重程度，类狼疮病变的存在可能与疾病的更严重过程有关。用于治疗皮肤病变的治疗方法包括抗凝治疗、皮质类固醇和抗组胺药。了解与 SARS-CoV-2 相关的皮肤表现有助于诊断有呼吸道症状相关皮肤病变的 COVID-19 患者或无症状患者。此外，了解与 COVID-19 相关的皮肤病变可能有助于制定个性化的护理计划。
