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论蛋白质的跨膜转运

On the translocation of proteins across membranes.

作者信息

Singer S J, Maher P A, Yaffe M P

出版信息

Proc Natl Acad Sci U S A. 1987 Feb;84(4):1015-9. doi: 10.1073/pnas.84.4.1015.

DOI:10.1073/pnas.84.4.1015
PMID:3469644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC304352/
Abstract

Many proteins of intracellular organelles are first synthesized in the cytoplasm and are then specifically transferred across the membranes of the organelles. On the assumption that these transfers all occur by the same basic mechanism, we enumerate the rather stringent requirements that the mechanism must satisfy. A unitary molecular mechanism is then proposed that meets these requirements.

摘要

许多细胞内细胞器的蛋白质首先在细胞质中合成，然后特异性地穿过细胞器的膜。假设这些转运都通过相同的基本机制发生，我们列举了该机制必须满足的相当严格的要求。然后提出了一种满足这些要求的统一分子机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/b1d087a736c2/pnas00269-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/29b8680db461/pnas00269-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/6ee1de980b7a/pnas00269-0123-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/174f63912716/pnas00269-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/b1d087a736c2/pnas00269-0124-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/29b8680db461/pnas00269-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/6ee1de980b7a/pnas00269-0123-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/174f63912716/pnas00269-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a27/304352/b1d087a736c2/pnas00269-0124-b.jpg

相似文献

1
On the translocation of proteins across membranes.论蛋白质的跨膜转运
Proc Natl Acad Sci U S A. 1987 Feb;84(4):1015-9. doi: 10.1073/pnas.84.4.1015.
2
Membrane translocation of proteins without hydrophobic signal peptides.无疏水信号肽的蛋白质的膜易位
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3
Protein import into mitochondria: a paradigm for the translocation of polypeptides across membranes.蛋白质导入线粒体：多肽跨膜转运的范例。
Curr Opin Cell Biol. 1993 Aug;5(4):694-700. doi: 10.1016/0955-0674(93)90142-d.
4
Mechanisms of translocation of proteins across membranes.
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5
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6
Translocation of proteins across membranes.蛋白质跨膜转运
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9
Intracellular sterol transport and distribution.细胞内固醇的运输与分布
Curr Opin Cell Biol. 2006 Aug;18(4):379-85. doi: 10.1016/j.ceb.2006.06.012. Epub 2006 Jun 27.
10
Protein transport. A fusion of new ideas.蛋白质转运。新思想的融合。
Nature. 1997 May 8;387(6629):133-5. doi: 10.1038/387133a0.

引用本文的文献

1
Transport of proteins into chloroplasts.蛋白质向叶绿体的转运。
Photosynth Res. 1988 Jul;17(1-2):173-94. doi: 10.1007/BF00047688.
2
Recent developments in chloroplast protein transport.叶绿体蛋白转运的最新进展。
Photosynth Res. 1988 Jan;19(1-2):153-84. doi: 10.1007/BF00114573.
3
Regulation of cyanobacterial pigment-protein composition and organization by environmental factors.环境因素对蓝藻色素-蛋白组成和结构的调控。

本文引用的文献

1
The cleavable pre-sequence of an imported chloroplast protein directs attached polypeptides into yeast mitochondria.被导入的叶绿体蛋白的可切割前导序列将连接的多肽引导进入酵母线粒体。
EMBO J. 1986 Jun;5(6):1343-50. doi: 10.1002/j.1460-2075.1986.tb04365.x.
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Secretion in yeast: translocation and glycosylation of prepro-alpha-factor in vitro can occur via an ATP-dependent post-translational mechanism.酵母中的分泌：体外前原α因子的转运和糖基化可通过一种依赖ATP的翻译后机制发生。
EMBO J. 1986 May;5(5):1031-6. doi: 10.1002/j.1460-2075.1986.tb04318.x.
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The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis.
Photosynth Res. 1988 Oct;18(1-2):133-61. doi: 10.1007/BF00042982.
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Conformation of protein secreted across bacterial outer membranes: a study of enterotoxin translocation from Vibrio cholerae.跨细菌外膜分泌的蛋白质构象：霍乱弧菌肠毒素易位的研究
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7418-22. doi: 10.1073/pnas.84.21.7418.
5
On the transfer of integral proteins into membranes.关于整合蛋白向膜内的转移。
Proc Natl Acad Sci U S A. 1987 Apr;84(7):1960-4. doi: 10.1073/pnas.84.7.1960.
6
Microinjected ribonuclease A as a probe for lysosomal pathways of intracellular protein degradation.显微注射的核糖核酸酶A作为细胞内蛋白质降解溶酶体途径的探针。
J Protein Chem. 1988 Apr;7(2):115-27. doi: 10.1007/BF01025241.
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Degradation of a signal peptide by protease IV and oligopeptidase A.信号肽被蛋白酶IV和寡肽酶A降解。
J Bacteriol. 1988 Nov;170(11):5067-75. doi: 10.1128/jb.170.11.5067-5075.1988.
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Effect of mutations on the binding and translocation functions of a chloroplast transit peptide.突变对叶绿体转运肽的结合和转运功能的影响。
Proc Natl Acad Sci U S A. 1989 Feb;86(3):886-90. doi: 10.1073/pnas.86.3.886.
9
Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli.SecY蛋白的拓扑结构分析，SecY蛋白是一种参与大肠杆菌蛋白质输出的整合膜蛋白。
EMBO J. 1987 Nov;6(11):3465-70. doi: 10.1002/j.1460-2075.1987.tb02670.x.
10
Protein translocation across the endoplasmic reticulum membrane: identification by photocross-linking of a 39-kD integral membrane glycoprotein as part of a putative translocation tunnel.蛋白质在内质网膜上的转运：通过光交联鉴定一种39-kD整合膜糖蛋白作为假定转运通道的一部分。
J Cell Biol. 1989 Nov;109(5):2033-43. doi: 10.1083/jcb.109.5.2033.
蛋白质自发插入和穿过膜：螺旋发夹假说。
Cell. 1981 Feb;23(2):411-22. doi: 10.1016/0092-8674(81)90136-7.
4
Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.蛋白质在内质网上的转运III. 信号识别蛋白（SRP）导致依赖信号序列和位点特异性的链延伸停滞，这种停滞可被微粒体膜解除。
J Cell Biol. 1981 Nov;91(2 Pt 1):557-61. doi: 10.1083/jcb.91.2.557.
5
Secretory protein translocation across membranes-the role of the "docking protein'.分泌蛋白跨膜转运——“对接蛋白”的作用
Nature. 1982 Jun 24;297(5868):647-50. doi: 10.1038/297647a0.
6
Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase.两个具有不同5'端且差异调控的mRNA编码酵母转化酶的细胞内形式和分泌形式。
Cell. 1982 Jan;28(1):145-54. doi: 10.1016/0092-8674(82)90384-1.
7
Intracellular protein topogenesis.细胞内蛋白质拓扑结构生成
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1496-500. doi: 10.1073/pnas.77.3.1496.
8
The signal sequence of ovalbumin is located near the NH2 terminus.卵清蛋白的信号序列位于氨基末端附近。
J Biol Chem. 1982 Oct 25;257(20):12245-51.
9
Determinants for protein localization: beta-lactamase signal sequence directs globin across microsomal membranes.蛋白质定位的决定因素：β-内酰胺酶信号序列引导珠蛋白穿过微粒体膜。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):456-60. doi: 10.1073/pnas.81.2.456.
10
Three-dimensional structure of membrane and surface proteins.膜蛋白和表面蛋白的三维结构。
Annu Rev Biochem. 1984;53:595-623. doi: 10.1146/annurev.bi.53.070184.003115.