单纯疱疹病毒：DNA 复制的机制。
Herpes simplex viruses: mechanisms of DNA replication.
机构信息
Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3205, USA.
出版信息
Cold Spring Harb Perspect Biol. 2012 Sep 1;4(9):a013011. doi: 10.1101/cshperspect.a013011.
Abstract
Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis-UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.
摘要
单纯疱疹病毒 (HSV) 编码七种病毒 DNA 合成所必需的蛋白 - UL9（起始结合蛋白）、ICP8（单链 DNA [ssDNA] 结合蛋白）、UL30/UL42（聚合酶）和 UL5/UL8/UL52（解旋酶/引发酶）。我们旨在提供对这些复制蛋白结构及其在 HSV 复制过程中功能的最新分析。还将讨论宿主修复和重组蛋白的潜在作用。
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