Virology Lab, Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
Department of Veterinary Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.
Viruses. 2021 Oct 11;13(10):2041. doi: 10.3390/v13102041.
Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (), was assembled and described using next-generation sequencing and bioinformatics analysis. The comparison of the whole-genome sequence and the conserved amino acid sequence of replicated proteins revealed that the new strain was distantly related with other known species in the genus. Phylogenetic construction indicated that this strain formed a separated branch with other species, suggesting a new species of . Additionally, prediction also revealed the risk of cross-species infection of this strain, especially in the order Artiodactyla. In summary, this study provided the genetic characteristics of a possible new species belonging to
冠状病毒是一种重要的人畜共患病，引发了人们对未来大流行的担忧。蝙蝠被认为是导致人类和家畜感染的显著病毒的来源，尤其是冠状病毒。因此，对蝙蝠中的冠状病毒进行监测和遗传分析对于预防未来疾病的风险至关重要。在这项研究中，使用下一代测序和生物信息学分析，对在蝙蝠中检测到的新型甲型冠状病毒 HCQD-2020 的基因组进行了组装和描述。对全基因组序列和复制蛋白保守氨基酸序列的比较表明，新毒株与属中的其他已知种属关系较远。系统进化构建表明，该毒株与其他种属形成了一个分离的分支，提示可能形成了一个新的种属。此外，预测还表明该毒株存在跨种属感染的风险，尤其是在偶蹄目动物中。总之，本研究提供了可能属于的新种属的遗传特征
