Programa de Pós-graduação em Inovação Terapêutica, Centro de Biociências, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil.
Programa de Pós-graduação em Inovação Terapêutica, Centro de Biociências, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil; Laboratório de Imunopatologia e Biologia Molecular, Departamento de Imunologia, Instituto Aggeu Magalhães, Cidade Universitária, Recife, Pernambuco, Brazil; Laboratório de Parasitologia, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil.
Cytokine Growth Factor Rev. 2021 Dec;62:15-22. doi: 10.1016/j.cytogfr.2021.10.001. Epub 2021 Oct 13.
Chagas disease is an important neglected disease that affects 6-7 million people worldwide. The disease has two phases: acute and chronic, in which there are different clinical symptoms. Controlling the infection depends on innate and acquired immune responses, which are activated during the initial infection and are critical for host survival. Furthermore, the immune system plays an important role in the therapeutic success. Here we summarize the importance of the immune system cytokines in the pathology outcome, as well as in the treatment.
恰加斯病是一种重要的被忽视疾病，影响全球 600 万至 700 万人。该病有两个阶段：急性和慢性，其中有不同的临床症状。控制感染取决于先天和获得性免疫反应，这些反应在初次感染时被激活，对宿主的生存至关重要。此外，免疫系统在治疗成功中起着重要作用。在这里，我们总结了免疫系统细胞因子在发病机制和治疗中的重要性。
