Høglund Rune A Aa, Meyer Haakon E, Stigum Hein, Torkildsen Øivind, Grytten Nina, Holmøy Trygve, Nakken Ola
From the Department of Neurology (R.A.A.H., T.H., O.N.), Akershus University Hospital, Lørenskog; Norwegian Institute of Public Health (H.E.M., H.S.); Department of Community Medicine and Global Health (H.E.M., H.S.) and Institute of Clinical Medicine (T.H.), University of Oslo; Department of Clinical Medicine (O.T., N.G.), University of Bergen; Neuro-SysMed (O.T.), Department of Neurology, Haukeland University Hospital; and Norwegian Multiple Sclerosis Competence Centre (N.G.), Department of Neurology, Haukeland University Hospital, Bergen, Norway.
Neurology. 2021 Dec 7;97(23):e2253-e2261. doi: 10.1212/WNL.0000000000012957. Epub 2021 Oct 25.
To prospectively investigate the long-term relationship between body mass index (BMI) in adolescents and young adults and risk for multiple sclerosis (MS) at the population level.
We used data from the population-based compulsory Norwegian tuberculosis screening program during 1963 to 1975, including objectively measured height and weight from ≈85% of all eligible citizens. This was combined with data from the Norwegian MS registry and biobank up to November 2020. BMI was standardized according to age and sex, and risk for MS was calculated with Cox proportional hazard models.
During 30,829,506 years of follow-up, we found 1,409 cases of MS among 648,734 participants in eligible age groups (14-34 years). Overall, obesity was associated with increased MS risk (hazard ratio [HR] 1.53 [95% confidence interval (CI) 1.25-1.88]), and the risk was similar in men (HR 1.4 [95% CI 0.95-2.06] and women (HR 1.59 [95% CI 1.25-2.02]). Risk was highest for the youngest age groups (age 14-16: HR 1.73 [95% CI 1.19-2.53]; 17-19: HR 1.61 [95% CI 1.08-2.39]; 20-24: HR 1.56 [95% CI 1.04-2.36]) and was no longer present for those >30 years of age.
High BMI in individuals 14 to 24 years of age was associated with increased MS risk later in life in both male and female individuals.
前瞻性研究青少年和青年的体重指数（BMI）与人群层面多发性硬化症（MS）风险之间的长期关系。
我们使用了1963年至1975年基于人群的挪威强制性结核病筛查项目的数据，包括约85%符合条件公民的客观测量身高和体重。这与截至2020年11月的挪威MS登记处和生物样本库的数据相结合。BMI根据年龄和性别进行标准化，并使用Cox比例风险模型计算MS风险。
在30829506人年的随访期间，我们在符合条件年龄组（14 - 34岁）的648734名参与者中发现了1409例MS病例。总体而言，肥胖与MS风险增加相关（风险比[HR] 1.53 [95%置信区间（CI）1.25 - 1.88]），男性（HR 1.4 [95% CI 0.95 - 2.06]）和女性（HR 1.59 [95% CI 1.25 - 2.02]）的风险相似。最年轻年龄组的风险最高（14 - 16岁：HR 1.73 [95% CI 1.19 - 2.53]；17 - 19岁：HR 1.61 [95% CI 1.08 - 2.39]；20 - 24岁：HR 1.56 [95% CI 1.04 - 2.36]），30岁以上人群不再有此风险。
14至24岁个体的高BMI与男性和女性日后生活中MS风险增加相关。
