Natesan Vijayakumar, Kim Sung-Jin
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India.
Department of Pharmacology and Toxicology, Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomol Ther (Seoul). 2021 Nov 1;29(6):596-604. doi: 10.4062/biomolther.2021.122.
Different lifestyles have an impact on useful metabolic functions, causing disorders. Different lipids are involved in the metabolic functions that play various vital roles in the body, such as structural components, storage of energy, in signaling, as biomarkers, in energy metabolism, and as hormones. Inter-related disorders are caused when these functions are affected, like diabetes, cancer, infections, and inflammatory and neurodegenerative conditions in humans. During the Covid-19 period, there has been a lot of focus on the effects of metabolic disorders all over the world. Hence, this review collectively reports on research concerning metabolic disorders, mainly cardiovascular and diabetes mellitus. In addition, drug research in lipid metabolism disorders have also been considered. This review explores lipids, metabolism, lipid metabolism disorders, and drugs used for these disorders.
不同的生活方式会对有益的代谢功能产生影响,从而引发紊乱。不同的脂质参与了在身体中发挥各种重要作用的代谢功能,如作为结构成分、能量储存、信号传导、生物标志物、能量代谢以及激素。当这些功能受到影响时,就会引发相互关联的紊乱,如人类的糖尿病、癌症、感染以及炎症和神经退行性疾病。在新冠疫情期间,全世界都非常关注代谢紊乱的影响。因此,本综述集中报道了有关代谢紊乱的研究,主要是心血管疾病和糖尿病。此外,还考虑了脂质代谢紊乱方面的药物研究。本综述探讨了脂质、代谢、脂质代谢紊乱以及用于这些紊乱的药物。