Zhang Meng, Li Lei, An Heng, Zhang Peixun, Liu Peilai
Department of Orthopedics and Trauma, Peking University People's Hospital, Beijing 100044, China.
Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100044, China.
Gels. 2021 Sep 27;7(4):152. doi: 10.3390/gels7040152.
Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.
周围神经损伤常发生于年轻人，其特点是再生机制复杂、预后不良且恢复缓慢，这不仅给患者造成心理障碍，还给社会带来沉重负担，成为临床医学中的一个根本问题。促进周围神经再生需要多个步骤。作为一种生物修复材料，自组装肽（SAP）水凝胶已引起国际关注。它们不仅可以设计成具有不同特性，还可通过促进细胞增殖或药物负载缓释应用于周围神经损伤的修复。SAP水凝胶在组织工程中广泛应用，已成为研究热点。它们具有广阔的应用前景和巨大的潜在生物学价值。本文综述了SAP水凝胶在周围神经损伤修复中的应用，并讨论了肽复合材料及制备技术的最新进展。
