Liu Chang, Zhang Qingguo, Zhu Song, Liu Hong, Chen Jie
School and Hospital of Stomatology, Jilin University Changchun 130021 P. R. China
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun 130022 P. R. China
RSC Adv. 2019 Sep 9;9(48):28299-28311. doi: 10.1039/c9ra05934b. eCollection 2019 Sep 3.
injectable hydrogels have shown tremendous potential application in the biomedical field due to their significant drug accumulation at lesion sites, sustained release and markedly reduced systemic side effects. Specifically, peptide-based hydrogels, with unique biodegradation, biocompatibility, and bioactivity, are attractive molecular skeletons. In addition, peptides play a prominent role in normal metabolism, mimicking the natural tissue microenvironment and responding to stimuli in the lesion environment. Their advantages endow peptide-based hydrogels with great potential for application as biomedical materials. In this review, the fabrication and production of peptide-based hydrogels are presented. Several promising candidates, which are smart and environment-sensitive, are briefly reviewed. Then, the recent developments of these hydrogels for biomedical applications in tissue engineering, as drug/gene vehicles, and anti-bacterial agents are discussed. Finally, the development of peptide-based injectable hydrogels for biomedical applications in the future is surveyed.
由于可注射水凝胶在病变部位具有显著的药物蓄积、缓释作用，并能显著降低全身副作用，因此在生物医学领域显示出巨大的潜在应用价值。具体而言，基于肽的水凝胶具有独特的生物降解性、生物相容性和生物活性，是颇具吸引力的分子骨架。此外，肽在正常代谢中发挥着重要作用，能够模拟天然组织微环境并对病变环境中的刺激作出反应。它们的优势使基于肽的水凝胶作为生物医学材料具有巨大的应用潜力。在这篇综述中，介绍了基于肽的水凝胶的制备和生产。简要综述了几种具有智能性和环境敏感性的、有前景的候选材料。然后，讨论了这些水凝胶在组织工程、作为药物/基因载体以及抗菌剂等生物医学应用方面的最新进展。最后，展望了基于肽的可注射水凝胶在未来生物医学应用中的发展。
