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北美本土麻风病:加拿大的第二例病例。

Autochthonous North American Leprosy: A Second Case in Canada.

作者信息

Naidu Prenilla, Sharma Rahul, Kanji Jamil N, Marks Vilma, King Arienne

机构信息

Public Health Laboratory, Alberta Precision Laboratories, University of Alberta Hospital, Edmonton, AB T6G 2J2, Canada.

Department of Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.

出版信息

Infect Dis Rep. 2021 Oct 22;13(4):917-923. doi: 10.3390/idr13040083.

DOI:10.3390/idr13040083
PMID:34698226
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8544447/
Abstract

Autochthonous leprosy was reported in the Southern USA in 2011 and has comprised an average of 34% of new cases from 2015 to 2020 in that country. We report a similar case in a patient from Western Canada. A 50-year old male patient presented with a four-year history of a chronic rash. Pathology stains revealed acid-fast bacilli prompting specialist referral. Examination was suspicious for leprosy, which was confirmed on slit skin smears and molecular testing. The patient responded well to treatment. Genotypic testing mapped the organism to the 3I-2 SNP type, which is of European origin and is the type found in implicated armadillo species in North America.

摘要

2011年美国南部报告了本土麻风病病例,从2015年到2020年,该国新病例中本土麻风病病例平均占34%。我们报告了一名来自加拿大西部患者的类似病例。一名50岁男性患者有四年慢性皮疹病史。病理染色发现抗酸杆菌,促使其转诊至专科医生处。检查怀疑为麻风病,经皮肤涂片和分子检测得以确诊。该患者对治疗反应良好。基因分型检测将该病原体定位为3I-2 SNP型,其起源于欧洲,也是在北美有牵连的犰狳物种中发现的类型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/8544447/ae2613a87bae/idr-13-00083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/8544447/ddcaaaf9aa3b/idr-13-00083-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/8544447/ae2613a87bae/idr-13-00083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/8544447/ddcaaaf9aa3b/idr-13-00083-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/8544447/ae2613a87bae/idr-13-00083-g002.jpg

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Low rate of relapse after twelve-dose multidrug therapy for hansen's disease: A 20-year cohort study in a brazilian reference center.20 年队列研究显示,12 剂多药疗法治疗麻风病后复发率低:巴西参考中心的研究。
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