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[光学相干断层扫描技术的进展]

[Advances in optical coherence tomography].

作者信息

Ruini Cristel, Daxenberger Fabia, Gust Charlotte, Schuh Sandra, French Lars E, Welzel Julia, Sattler Elke C

机构信息

Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, LMU München, Frauenlobstr. 9-11, 80337, München, Deutschland.

Doctorate School (PhD) in Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italien.

出版信息

Hautarzt. 2021 Dec;72(12):1048-1057. doi: 10.1007/s00105-021-04905-2. Epub 2021 Oct 26.

DOI:10.1007/s00105-021-04905-2
PMID:34698874
Abstract

Optical coherence tomography (OCT) has been able to establish itself in recent years not only in academic-scientific, but also in everyday dermatological practice. Its focus lies on epithelial tumors of the skin, which can be diagnosed intuitively and within a few seconds. Thus, basal cell carcinomas, actinic keratoses, and different stages of field cancerization can be diagnosed and monitored for response to therapy or possible recurrence. This often helps to avoid invasive sample extraction. Recently, the field of OCT and its latest advancement, dynamic OCT (D-OCT), has been expanded to include non-oncologic dermatological diseases. This encompasses inflammatory dermatoses and the analysis of physiological skin parameters such as hydration. Thanks to automated vascular imaging and the measurement of objective parameters such as epidermal thickness, blood flow at depth, optical attenuation coefficient, and skin roughness, more and more characteristics of the skin can be studied in a noninvasive and standardized way. New potential areas of application are eczema, contact allergic dermatitis, psoriasis, rosacea, telangiectasia, acute and chronic wounds, melasma and nevus flammeus but also melanocytic lesions.

摘要

近年来,光学相干断层扫描(OCT)不仅在学术科研领域站稳了脚跟,在日常皮肤科实践中也得到了广泛应用。它主要聚焦于皮肤上皮肿瘤,能够在短短几秒内直观地进行诊断。因此,基底细胞癌、光化性角化病以及不同阶段的场癌化都可以被诊断出来,并监测其对治疗的反应或是否可能复发。这常常有助于避免进行侵入性样本提取。最近,OCT领域及其最新进展——动态OCT(D-OCT),已扩展到涵盖非肿瘤性皮肤病。这包括炎症性皮肤病以及对皮肤生理参数(如水合作用)的分析。借助自动血管成像以及对诸如表皮厚度、深部血流、光学衰减系数和皮肤粗糙度等客观参数的测量,越来越多的皮肤特征能够以非侵入性和标准化的方式进行研究。新的潜在应用领域包括湿疹、接触性过敏性皮炎、银屑病、酒渣鼻、毛细血管扩张、急慢性伤口、黄褐斑和鲜红斑痣,还有黑素细胞病变。

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引用本文的文献

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Vascular characteristics of port wine birthmarks as measured by dynamic optical coherence tomography.动态光学相干断层扫描测量葡萄酒色斑的血管特征。
J Am Acad Dermatol. 2021 Dec;85(6):1537-1543. doi: 10.1016/j.jaad.2021.08.007. Epub 2021 Aug 11.
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Optical coherence tomography quantifying photo aging: skin microvasculature depth, epidermal thickness and UV exposure.光学相干断层扫描定量评估光老化:皮肤微血管深度、表皮厚度和紫外线暴露。
Arch Dermatol Res. 2022 Jul;314(5):469-476. doi: 10.1007/s00403-021-02245-8. Epub 2021 Jun 10.
3
Blood Vessel Density Measured Using Dynamic Optical Coherence Tomography is a Tool for Wound Healers.
使用动态光学相干断层扫描测量的血管密度是伤口愈合治疗师的一项工具。
Int J Low Extrem Wounds. 2023 Jun;22(2):235-240. doi: 10.1177/15347346211017334. Epub 2021 May 7.
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Attenuation corrected-optical coherence tomography for quantitative assessment of skin wound healing and scar morphology.衰减校正光学相干断层扫描定量评估皮肤伤口愈合和瘢痕形态。
J Biophotonics. 2021 Apr;14(4):e202000357. doi: 10.1002/jbio.202000357. Epub 2020 Dec 29.
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Dynamic optical coherence tomography shows characteristic alterations of blood vessels in malignant melanoma.动态光学相干断层扫描显示恶性黑色素瘤中血管的特征性改变。
J Eur Acad Dermatol Venereol. 2021 May;35(5):1087-1093. doi: 10.1111/jdv.17080. Epub 2021 Jan 5.
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Dynamic Optical Coherence Tomography of Cutaneous Blood Vessels in Melasma and Vessel Response to Oral Tranexamic Acid.动态光学相干断层扫描在黄褐斑皮肤血管中的应用及氨甲环酸口服后的血管反应
Lasers Surg Med. 2021 Aug;53(6):861-864. doi: 10.1002/lsm.23345. Epub 2020 Nov 8.
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Optical coherence tomography for patch test grading: A prospective study on its use for noninvasive diagnosis of allergic contact dermatitis.光学相干断层扫描在斑贴试验分级中的应用:一项前瞻性研究其在非侵入性诊断变应性接触性皮炎中的应用。
Contact Dermatitis. 2021 Mar;84(3):183-191. doi: 10.1111/cod.13714. Epub 2020 Oct 21.
8
Applications and future directions for optical coherence tomography in dermatology.光学相干断层扫描在皮肤科的应用及未来方向。
Br J Dermatol. 2021 Jun;184(6):1014-1022. doi: 10.1111/bjd.19553. Epub 2020 Nov 8.
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