• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

新世界首例分离次级代谢产物 Perezone 的时间线,涵盖 1852 年至 2020 年。

A Timeline of Perezone, the First Isolated Secondary Metabolite in the New World, Covering the Period from 1852 to 2020.

机构信息

Department of Industrial Maintenance and Nanotechnology, Technological University of Juarez City, 32695, Ciudad Juarez, Chihuahua, Mexico.

Department of Chemistry, Faculty of Superior Studies Cuautitlan, National Autonomous University of Mexico, Mexico State, Campus 1, 54740, Cuautitlan Izcalli, Mexico.

出版信息

Prog Chem Org Nat Prod. 2021;116:67-133. doi: 10.1007/978-3-030-80560-9_3.

DOI:10.1007/978-3-030-80560-9_3
PMID:34698946
Abstract

This chapter covers a sesquiterpene quinone, commonly named perezone. This molecule is documented as the first secondary metabolite isolated in crystalline form in the New World in 1852. An introduction, with its structure, the IUPAC nomenclature, and the most recent physical and spectroscopic characterizations are firstly described initially. Alongside this, a timeline and scheme with summarized information of the history of this molecule is given including the "Códice Badiano de la Cruz, 1552, highlighting the year of its isolation culminating with information up to 2005. Subsequently, in a chronological order the most recent advances of the target molecule are included and organized in subsections covering the last 15-year period 2006-2020. Finally, recently submitted contributions from the laboratory of the authors are described. It is important to note that the details provided highlight the importance and relevance of perezone.

摘要

本章介绍一种倍半萜醌,通常称为佩罗佐内。这种分子于 1852 年被记录为首次在新世界以结晶形式分离的次级代谢产物。本文首先介绍了它的结构、IUPAC 命名法以及最近的物理和光谱特性。此外,还提供了一个时间线和图表,总结了该分子的历史信息,包括 1552 年的《巴迪亚诺法典》,突出了其分离的年份,并一直延续到 2005 年的信息。随后,按照时间顺序,包含了目标分子最近的进展,并按最近 15 年(2006-2020 年)的时间段进行了分组。最后,还描述了作者实验室最近提交的研究成果。需要注意的是,提供的详细信息突出了佩罗佐内的重要性和相关性。

相似文献

1
A Timeline of Perezone, the First Isolated Secondary Metabolite in the New World, Covering the Period from 1852 to 2020.新世界首例分离次级代谢产物 Perezone 的时间线,涵盖 1852 年至 2020 年。
Prog Chem Org Nat Prod. 2021;116:67-133. doi: 10.1007/978-3-030-80560-9_3.
2
Green Approach Extraction of Perezone from the Roots of (A. Grey): A Comparison of Four Activating Modes and Supercritical Carbon Dioxide.绿色方法从 (A. Grey)根中提取派利酮:四种活化模式与超临界二氧化碳的比较。
Molecules. 2019 Aug 21;24(17):3035. doi: 10.3390/molecules24173035.
3
In vitro and computational studies showed that perezone inhibits PARP-1 and induces changes in the redox state of K562 cells.体外和计算研究表明,哌罗昔隆抑制 PARP-1 并诱导 K562 细胞氧化还原状态的变化。
Arch Biochem Biophys. 2019 Aug 15;671:225-234. doi: 10.1016/j.abb.2019.05.002. Epub 2019 May 4.
4
High variability of perezone content in rhizomes of wild plants, environmental factors related, and proteomic analysis.野生植物块茎中 perezone 含量的高度变异性,与环境因素有关,以及蛋白质组学分析。
PeerJ. 2023 Nov 15;11:e16136. doi: 10.7717/peerj.16136. eCollection 2023.
5
In silico Study of the Pharmacologic Properties and Cytotoxicity Pathways in Cancer Cells of Various Indolylquinone Analogues of Perezone.过氧紫罗酮的各种吲哚醌类似物在癌细胞中的药理特性和细胞毒性途径的计算机模拟研究
Molecules. 2017 Jun 25;22(7):1060. doi: 10.3390/molecules22071060.
6
Establishment of transformed root cultures of Perezia cuernavacana producing the sesquiterpene quinone perezone.建立产生倍半萜醌类化合物佩雷酮的佩雷西亚·库纳瓦坎转化根培养物。
Plant Cell Rep. 1996 Mar;15(7):455-8. doi: 10.1007/BF00232973.
7
5-Epi-isospongiaquinone, a new sesquiterpene/quinone antibiotic from an Australian marine sponge, Spongia hispida.5-表异海绵醌,一种从澳大利亚海洋海绵希氏海绵(Spongia hispida)中提取的新型倍半萜/醌类抗生素。
J Nat Prod. 1992 Nov;55(11):1638-42. doi: 10.1021/np50089a012.
8
Remote position substituents as modulators of conformational and reactive properties of quinones. Relevance of the pi/pi intramolecular interaction.作为醌类构象和反应性质调节剂的远程位置取代基。π/π分子内相互作用的相关性。
J Org Chem. 2007 Mar 16;72(6):1883-94. doi: 10.1021/jo061576v. Epub 2007 Feb 15.
9
The action of the sesquiterpenic benzoquinone, perezone, on electron transport in biological membranes.倍半萜苯醌派热酮对生物膜中电子传递的作用。
Arch Biochem Biophys. 1988 Jan;260(1):293-300. doi: 10.1016/0003-9861(88)90453-5.
10
Ca2+ releasing effect of perezone on adrenal cortex mitochondria.土荆芥酮对肾上腺皮质线粒体的钙离子释放作用。
Life Sci. 1987 Oct 26;41(17):2047-54. doi: 10.1016/0024-3205(87)90479-6.

引用本文的文献

1
Theoretical-Cheminformatic Study of Four Indolylphytoquinones, Prospective Anticancer Candidates.四种吲哚基植物醌的理论化学信息学研究:潜在的抗癌候选物
Pharmaceuticals (Basel). 2024 Nov 26;17(12):1595. doi: 10.3390/ph17121595.
2
Design of Two New Sulfur Derivatives of Perezone: In Silico Study Simulation Targeting PARP-1 and In Vitro Study Validation Using Cancer Cell Lines.设计两个新的帕瑞肽硫代衍生物:针对 PARP-1 的计算机模拟研究和使用癌细胞系的体外研究验证。
Int J Mol Sci. 2024 Jan 10;25(2):868. doi: 10.3390/ijms25020868.
3
High variability of perezone content in rhizomes of wild plants, environmental factors related, and proteomic analysis.

本文引用的文献

1
In vitro and computational studies showed that perezone inhibits PARP-1 and induces changes in the redox state of K562 cells.体外和计算研究表明,哌罗昔隆抑制 PARP-1 并诱导 K562 细胞氧化还原状态的变化。
Arch Biochem Biophys. 2019 Aug 15;671:225-234. doi: 10.1016/j.abb.2019.05.002. Epub 2019 May 4.
2
Antidiabetic and Antihyperalgesic Effects of a Decoction and Compounds from Acourtia thurberi.瑟伯阿克提亚煎剂及其化合物的抗糖尿病和抗痛觉过敏作用
Planta Med. 2017 Apr;83(6):534-544. doi: 10.1055/s-0042-119652. Epub 2016 Nov 4.
3
Establishment of transformed root cultures of Perezia cuernavacana producing the sesquiterpene quinone perezone.
野生植物块茎中 perezone 含量的高度变异性,与环境因素有关,以及蛋白质组学分析。
PeerJ. 2023 Nov 15;11:e16136. doi: 10.7717/peerj.16136. eCollection 2023.
建立产生倍半萜醌类化合物佩雷酮的佩雷西亚·库纳瓦坎转化根培养物。
Plant Cell Rep. 1996 Mar;15(7):455-8. doi: 10.1007/BF00232973.
4
A Novel Semisynthetic Anion Receptor: Synthesis and Ion Recognition of (1-H-pyrrol-2-yl)-4-oxo-perezone.一种新型半合成阴离子受体:(1-H-吡咯-2-基)-4-氧代-紫苏酮的合成与离子识别
Lett Org Chem. 2013 Nov;10:632-636. doi: 10.2174/15701786113109990035.
5
[5 + 2] cycloaddition reactions in organic and natural product synthesis.有机合成和天然产物合成中的[5 + 2]环加成反应
Chem Rev. 2013 Mar 13;113(3):2244-66. doi: 10.1021/cr300087g. Epub 2012 Nov 15.
6
Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone.从佩雷佐恩中合成、细胞毒性和抗氧化评价的氨基酸衍生物。
Bioorg Med Chem. 2012 Sep 1;20(17):5077-84. doi: 10.1016/j.bmc.2012.07.027. Epub 2012 Jul 25.
7
Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death.派罗尼醇及其异构体异派罗尼醇诱导细胞发生 caspase 依赖性和非依赖性死亡。
Phytomedicine. 2010 Jul;17(8-9):614-20. doi: 10.1016/j.phymed.2009.12.011. Epub 2010 Jan 25.
8
Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma.筛选一组具有不同作用机制的药物,可获得针对神经母细胞瘤的潜在治疗药物。
Cancer Biol Ther. 2009 Dec;8(24):2386-95. doi: 10.4161/cbt.8.24.10184. Epub 2009 Dec 27.
9
Effect of perezone on arrhythmias and markers of cell injury during reperfusion in the anesthetized rat.哌瑞宗对麻醉大鼠再灌注期间心律失常及细胞损伤标志物的影响。
Life Sci. 1999;65(16):1615-23. doi: 10.1016/s0024-3205(99)00411-7.
10
Effects of three Mexican medicinal plants (Asteraceae) on blood glucose levels in healthy mice and rabbits.三种墨西哥药用植物(菊科)对健康小鼠和兔子血糖水平的影响。
J Ethnopharmacol. 1997 Feb;55(3):171-7. doi: 10.1016/s0378-8741(96)01494-8.