5-表异海绵醌，一种从澳大利亚海洋海绵希氏海绵（Spongia hispida）中提取的新型倍半萜/醌类抗生素。

5-Epi-isospongiaquinone, a new sesquiterpene/quinone antibiotic from an Australian marine sponge, Spongia hispida.

作者信息

Urban S, Capon R J

机构信息

School of Chemistry, University of Melbourne, Victoria, Australia.

出版信息

J Nat Prod. 1992 Nov;55(11):1638-42. doi: 10.1021/np50089a012.

DOI:10.1021/np50089a012

PMID:1479380

Abstract

An Australian marine sponge, Spongia hispida, has been found to contain a new sesquiterpene/quinone identified by detailed spectroscopic analysis and chemical derivatization as the antibiotic 5-epi-isospongiaquinone [3]. The complete stereostructure for 3 was determined by detailed spectroscopic analysis and chemical correlation with the known marine natural product isospongiaquinone [2]. Co-occurring with 3 was an ethylated analogue, 5-epi-homoisospongiaquinone [4], which was speculated to be an artifact of the isolation process. A revised structure 15 for the known marine metabolite, smenorthoquinone [13], is also presented.

摘要

一种澳大利亚海洋海绵，即刺海绵（Spongia hispida），已被发现含有一种新的倍半萜/醌，通过详细的光谱分析和化学衍生化鉴定为抗生素5-表异海绵醌[3]。通过详细的光谱分析以及与已知海洋天然产物异海绵醌[2]的化学关联，确定了化合物3的完整立体结构。与化合物3同时存在的是一种乙基化类似物，5-表高异海绵醌[4]，推测它是分离过程中的一种人工产物。还给出了已知海洋代谢产物斯门正醌[13]的修订结构15。