Alarcon-Aguilar F J, Roman-Ramos R, Jimenez-Estrada M, Reyes-Chilpa R, Gonzalez-Paredes B, Flores-Saenz J L
Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana, México D.F., Mexico.
J Ethnopharmacol. 1997 Feb;55(3):171-7. doi: 10.1016/s0378-8741(96)01494-8.
The effects of Psacalium decompositum, Psacalium peltatum and Acourtia thurberi (Asteraceae) on blood glucose levels were investigated in fasting mice and temporally hyperglycemic rabbits. The root decoction of P. decompositum reduced the blood glucose of normal mice from 49.1 +/- 3.8 to 35.7 +/- 2.0 mg/dl after intraperitoneal administration (P < or = 0.005) and significantly lowered the hyperglycemic peak (17.1%) in rabbits with temporal hyperglycemia. P. peltatum and A. thurberi decoctions also diminished fasting glycemia in mice and hyperglycemia in rabbits, but the effects were minor. A preliminary phytochemical study using thin layer chromatography showed that water decoctions of the three roots contained alkaloids and sugars. P. decompositum and P. peltatum showed the presence of maturine. However, other furoeremophylanes, such as cacalol and cacalone were only present in P. decompositum. A. thurberi root water decoction showed the presence of the benzoquinone perezone, and its derivative pipitzol.
在禁食小鼠和暂时性高血糖兔中研究了裂叶假菊（Psacalium decompositum）、盾叶假菊（Psacalium peltatum）和瑟氏阿克菊（Acourtia thurberi，菊科）对血糖水平的影响。腹腔注射裂叶假菊根煎剂后，正常小鼠的血糖从49.1±3.8降至35.7±2.0mg/dl（P≤0.005），并显著降低了暂时性高血糖兔的高血糖峰值（17.1%）。盾叶假菊和瑟氏阿克菊煎剂也降低了小鼠的空腹血糖和兔的高血糖，但效果较小。使用薄层色谱法进行的初步植物化学研究表明，三种根的水煎剂含有生物碱和糖类。裂叶假菊和盾叶假菊显示含有马图灵。然而，其他呋喃艾里莫芬烷，如卡考醇和卡考酮仅存在于裂叶假菊中。瑟氏阿克菊根水煎剂显示含有苯醌派热酮及其衍生物哌匹唑。
