Bearson Shawn M D
Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, Agricultural Research Center, US Department of Agriculture, Ames, Iowa, USA; email:
Annu Rev Anim Biosci. 2022 Feb 15;10:373-393. doi: 10.1146/annurev-animal-013120-043304. Epub 2021 Oct 26.
An estimated 1.3 million infections and 420 deaths occur annually in the United States, with an estimated economic burden of $3.7 billion. More than 50% of US swine operations test positive for according to the National Animal Health Monitoring System, and 20% of from swine are multidrug resistant (resistant to ≥3 antimicrobial classes) as reported by the National Antimicrobial Resistance Monitoring System. This review on in swine addresses the current status of these topics by discussing antimicrobial resistance and metal tolerance in and the contribution of horizontal gene transfer. A major challenge in controlling is that is a foodborne pathogen in humans but is often a commensal in food animals and thereby establishes an asymptomatic reservoir state in such animals, including swine. As food animal production systems continue to expand and antimicrobial usage becomes more limited, the need for interventions has intensified. A promising mitigation strategy is vaccination against in swine to limit animal, environmental, and food contamination.
在美国，估计每年有130万例感染和420例死亡，估计经济负担为37亿美元。根据国家动物卫生监测系统的数据，超过50%的美国养猪场检测出[病原体名称]呈阳性，而国家抗菌药物耐药性监测系统报告称，20%的猪源[病原体名称]具有多重耐药性（对≥3类抗菌药物耐药）。这篇关于猪[病原体名称]的综述通过讨论[病原体名称]中的抗菌药物耐药性和金属耐受性以及水平基因转移的作用，阐述了这些主题的现状。控制[病原体名称]的一个主要挑战是，它是人类的食源性病原体，但在食用动物中通常是共生菌，从而在包括猪在内的此类动物中建立无症状的储存宿主状态。随着食用动物生产系统的不断扩大以及抗菌药物的使用变得更加受限，对[病原体名称]干预措施的需求也日益增加。一种有前景的缓解策略是给猪接种[病原体名称]疫苗，以限制动物、环境和食品污染。
