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靶向晚期 ICaL 以关闭致心律失常的心室窗口。

Targeting late ICaL to close the window to ventricular arrhythmias.

机构信息

Centro de Investigaciones Cardiovasculares Horacio Cingolani, CONICET La Plata, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina.

出版信息

J Gen Physiol. 2021 Dec 6;153(12). doi: 10.1085/jgp.202113009. Epub 2021 Oct 26.

DOI:10.1085/jgp.202113009
PMID:34699586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8552155/
Abstract

This commentary is on the paper by Angelini et al. Here, we set the original paper in the context of triggered arrhythmias, particularly early after depolarizations (EADs), emphasizing the importance of pharmacologically inhibiting late Ca current to prevent EADs without affecting myocardial contractility.

摘要

这篇评论是针对 Angelini 等人的论文而写的。在这里，我们将原始论文置于触发心律失常的背景下，特别是早期后除极 (EAD)，强调通过药理学抑制晚期 Ca 电流来预防 EAD 而不影响心肌收缩力的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26dd/8552155/b17039cb1cbb/JGP_202113009_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26dd/8552155/b17039cb1cbb/JGP_202113009_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26dd/8552155/b17039cb1cbb/JGP_202113009_Fig1.jpg

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The molecular determinants of R-roscovitine block of hERG channels.hERG 通道阻滞的 R-罗司卡品的分子决定因素。
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In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis.KCNA5基因变异的计算机模拟评估揭示了人类房性心律失常发生的多种机制。
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