Laboratório de Design Anatômico/LabDA, Departamento de Morfologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
Laboratório de Morfofisiologia Experimental e Comparada/LABITEX, Departamento de Morfologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
Res Vet Sci. 2021 Dec;141:81-94. doi: 10.1016/j.rvsc.2021.10.015. Epub 2021 Oct 20.
The morphological similarities of vertebrates' embryonic development are used as a criterion for choosing animal models that can be used in biomedical research. This study describes the embryonic and fetal development of the domestic cat's central nervous system from 15 days after conception until birth. In total, fifty-seven samples of embryos and fetuses were carefully dissected and analyzed microscopically. The closure of the neural tube was observed between 14-15th days of gestation. The differentiation of the primordial cerebral vesicles was observed from the 17th day of gestation. On the 19th day of gestation, the formation of the choroid plexus began, and on the 20th day of gestation, the brain and brainstem were well-identified macroscopically. On the 24th day of gestation, four layers of cells from the cerebral cortex were described, and on the 60th day, six layers of cells were present. The cerebellar cortex had the three classic cortical layers at this stage. The morphological aspects of embryonic and fetal development in cats were very similar to the stages of development of the human nervous system. As such, this study provided relevant information that highlights the domestic cat as an animal model option for preclinical research on infectious and non-infectious neurological diseases in humans.
脊椎动物胚胎发育的形态相似性被用作选择可用于生物医学研究的动物模型的标准。本研究描述了家猫中枢神经系统从受孕后 15 天到出生的胚胎和胎儿发育。总共仔细解剖和分析了 57 个胚胎和胎儿样本。在妊娠 14-15 天观察到神经管闭合。在妊娠第 17 天观察到原始脑泡的分化。妊娠第 19 天开始形成脉络丛，妊娠第 20 天大脑和脑干宏观上可以很好地区分。妊娠第 24 天描述了大脑皮层的四层细胞，妊娠第 60 天出现了六层细胞。小脑皮层在这个阶段具有三个经典的皮层层。猫的胚胎和胎儿发育的形态方面与人类神经系统的发育阶段非常相似。因此，本研究提供了相关信息，强调了家猫作为人类感染性和非感染性神经疾病临床前研究的动物模型选择。
