Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100006, China.
Sci China Life Sci. 2022 Jun;65(6):1123-1145. doi: 10.1007/s11427-020-1959-5. Epub 2021 Oct 21.
As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. The family Asteraceae possesses various compounds against C. neoformans, the family Anacardiaceae has compounds against Salmonella typhi, the family Cucurbitacea against the human immunodeficiency virus (HIV), and the family Ancistrocladaceae against Plasmodium. This review summarizes currently available data on NP-based antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents.
由于 2019 年冠状病毒病（COVID-19）在全球范围内威胁人类健康，传染病已成为医学界面临的最具挑战性问题之一。天然产物（NP）一直是抗菌剂的丰富来源，具有广泛不同的结构和广泛的生物活性。通过手动选择已发表的文章，组装了一个包含 618 篇文章的数据集，其中包括 646 种基于 NP 的化合物，这些化合物来自 672 种天然来源的物种，具有针对来自五个类别的 21 种传染病病原体的生物活性。这些数据用于识别 268 种基于 NP 的化合物，将其分为十个组，用于网络药理学分析，以捕获最有前途的先导化合物，如阿格拉西林 D、双香豆素、二氢青蒿素和吡啶霉素。最大 Tanimoto 得分的分布表明，抑制寄生虫的化合物多样性较低，而抑制细菌、真菌和病毒的化学物质显示出更高的结构多样性。共选择了 331 种具有抗菌活性的药用植物的化合物来分类科源。菊科植物含有多种针对新型隐球菌的化合物，漆树科植物含有多种针对伤寒沙门氏菌的化合物，葫芦科植物含有多种针对人类免疫缺陷病毒（HIV）的化合物，防己科植物含有多种针对疟原虫的化合物。本综述总结了目前关于针对难治性感染的基于 NP 的抗菌药物的可用数据，为进一步发现药物和抗感染药物的合成策略提供了信息。
